The Effect of Capsella bursa-pastoris Extract on Heavy Menstrual Bleeding and Quality of Life in Patients with Uterine Leiomyoma: A Double-blind Randomized Clinical Trial
Atieh Sadat Danesh, Faraz Mojab, Abolfazl Mohammadbeigi, Soodabeh Bioos, Zahra Siaghati, Fatemeh Nojavan
Journal of Pharmaceutical Research International · pp. 1–10 · Published 9 Nov 2019
10.9734/jpri/2019/v31i330303Abstract
Objectives: Heavy Menstrual Bleeding (HMB) is the most important problems of Uterine Leiomyoma (UL). This study aimed to assess the effect of the extract of the Capsella bursa-pastoris (CBP) on the control of HMB and quality of life in patients with uterine leiomyoma. Design: In a double-blind randomized, clinical trial 54 women with uterine leiomyoma were randomly assigned to the intervention/control groups by block randomization. Setting: Gynecology outpatient clinics. Intervention: The intervention group received 350 mg of alcoholic extract of Capsella bursa-pastoris and the control group received placebo twice daily for three months. Main Outcome Measures: Amount of bleeding by Pictorial blood loss assessment chart (PBAC), quality of life by menstrual quality of life questionnaires (MQ) and bleeding duration by calendar were evaluated. Results: The mean of PBAC decreased from 464.00± 283.61 at baseline to 323.82±207.66 in the intervention group and decreased from 445.92±362.64 to 214.36±137.68 in control group in the third month. The improvement trend was significant in the two groups, but there was no significant difference between groups. The mean of bleeding duration and menstrual quality of life showed improvement in patients of two groups without significant difference between the two groups. Conclusion: Despite the effectiveness of CBP in the intervention group in decreasing of PBAC score and menstrual bleeding duration and improvement of menstrual quality of life in patients who suffered from UL, it did not show a significant effect compared to the control group. Future studies with a larger sample size in one specific type of UL suggested.
References (23)
- 1 Uterine fibroid management: from the present to the future [DOI]
- 2 Epidemiology of Uterine Fibroids [DOI]
- 3 Uterine Fibroids: Diagnosis and Treatment.
- 4 Botanical drugs and preparations in the traditional medicine of West Azerbaijan (Iran) [DOI]
- 5 Total Phenolic, Total Flavonoid, Tannin Content, and Antioxidant Capacity of Halimium halimifolium (Cistaceae) [DOI]
- 6 Ethnoveterinary medicines used for ruminants in British Columbia, Canada [DOI]
- 7 Uterine Leiomyoma: Available Medical Treatments and New Possible Therapeutic Options [DOI]
- 8 Analysis of phenolic compounds in different parts of pomegranate (Punica granatum) fruit by HPLC-PDA-ESI/MS and evaluation of their antioxidant activity: application to different Italian varieties [DOI]
- 9 Evaluation and Management of Abnormal Uterine Bleeding [DOI]
- 10 Literature Review on the Role of Uterine Fibroids in Endometrial Function [DOI]
- 11 Chemical composition and biological screening of Capsella bursa-pastoris [DOI]
- 12 Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: Promising options for prevention and treatment of uterine fibroids? [DOI]
- 13 Medicinal plants in the treatment of women's disorders: Analytical strategies to assure quality, safety and efficacy [DOI]
- 14 Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse [DOI]
- 15 Contribution to the traditional uses of medicinal plants of Turgutlu (Manisa – Turkey) [DOI]
- 16 Pictorial blood loss assessment chart for quantification of menstrual blood loss: a systematic review [DOI]
- 17 Effect of Hydroalcoholic Extract of Capsella bursa pastoris on Early Postpartum Hemorrhage: A Clinical Trial Study [DOI]
- 18 The effect of frankincense (Boswellia serrata, oleoresin) and ginger (Zingiber officinale, rhizoma) on heavy menstrual bleeding: A randomized, placebo-controlled, clinical trial [DOI]
- 19 Comparison of the Hemostatic Activity of Quercus persica Jaub. & Spach. (Oak) With Ferric Sulfate in Bony Crypts [DOI]
- 20 Evaluation of efficacy of Punica granatum L. (Persian gulnar) on uterine leiomyoma related menorrhagia: a pilot study [DOI]
- 21 Inhibition of nitric oxide production corresponds to the sulforaphane content in Korean sheperd’s purse (Capsella bursa-pastoris) and related species in BV-2 cell [DOI]
- 22 THE MENORRHAGIA QUESTIONNAIRE (MQ): TRANSLATION AND VALIDATION STUDY OF THE IRANIAN VERSION
- 23 The Comparative Effect of Capsella bursa-pastoris and Mefenamic Acid on Sexual Function of Copper IUD Users [DOI]
Cited by 8
Safa GÜMÜŞOK, Damla KIRCI, Betül DEMIRCI · Turkish Journal of Pharmaceutical Sciences · 2023
Moloud Fakhri, Zeinab HamzehGardeshi, Seyde Sedighe Yousefi · Journal of Nursing and Midwifery Sciences · 2023
Akingbolabo Daniel Ogunlakin, Divine Sokoato Anejukwo, Olubunmi Asaleye · Vegetos · 2025
Showing 3 of 8 known citations — external sources report more than can currently be individually listed.
Related research
- Does Pain Adversely Affect the Quality of Life in Hospitalized Cancer Patients? — shares topic coverage
- Psychosocial Determinants of Quality of Life and Mental Health Status of Caregivers of Children with Psychopathologies in Lagos Nigeria — shares topic coverage
- Psychological Impact of Diabetic Care on Satisfaction and Quality of Life of Diabetes Patients Attending Endocrinology Clinic, LAUTECH Teaching Hospital, Osun State, Southwest, Nigeria — shares topic coverage
- The Effect of Long COVID Syndrome Degree Severity on the Quality of Life of COVID-19 Survivors Aged 15-64 Years Old at Gotong Royong Hospital, Surabaya — shares topic coverage
- Vitamin D: A Key Factor in Prostate Health — shares topic coverage
Article metrics
Real usage data collected on this platform.
11
Page views
0
PDF downloads
0
Outbound clicks
8
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.