Synthesis of Novel 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine Derivatives and  In-vitro Evaluation of their Antitumor and Antibacterial Activities

J. Paveendra; H. M. Vagdevi

doi:10.9734/jpri/2023/v35i137367

Research Article Open access CC BY 4.0

Synthesis of Novel 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine Derivatives and In-vitro Evaluation of their Antitumor and Antibacterial Activities

J. Paveendra, H. M. Vagdevi

Journal of Pharmaceutical Research International · pp. 25–35 · Published 23 May 2023

10.9734/jpri/2023/v35i137367

Abstract

Benzoxazole is one of the biologically important heterocyclic compounds, which shows remarkable pharmacological activities. In this work, 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine derivatives have been synthesized by using mild protocol under solvent free condition. Structures of the synthesized compounds have been confirmed through IR, 1H NMR, 13C NMR and Mass spectral methods. All the compounds were assessed for their antitumor and antibacterial activities. 6h has found remarkable activity on both antitumor and antibacterial studies and 6g and 6a exhibited promising antibacterial and antitumor activity. Simple work up technique, good yield and use of environmental-friendly reagents are of the reaching features of the present work.

Benzoxazole solvent free condition antitumor antibacterial

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J. Paveendra, H. M. Vagdevi (2023). Synthesis of Novel 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine Derivatives and In-vitro Evaluation of their Antitumor and Antibacterial Activities. Journal of Pharmaceutical Research International , 25–35. https://doi.org/10.9734/jpri/2023/v35i137367

Affiliations

J. Paveendra — Department of Chemistry, Sahyadri Science College, Shivamogga-577203, India.
H. M. Vagdevi — Sahyadri Science College, Shivamogga-577203, India.

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