Synthesis, Insilico and Antibacterial Activity Studies of Substituted Dihydro-1, 2-Oxazole Benzopyran-2-One Hybrids
Alphonsus D’souza, Pankaj Kumar, Abhishek Kumar, Soundarya M. Rai, Prashant Nayak
Journal of Pharmaceutical Research International · pp. 134–144 · Published 5 Jul 2021
10.9734/jpri/2021/v33i35A31882Abstract
A series of substituted dihydro-1, 2-oxazole benzopyran-2-one (SR1-SR6) were synthesized through the intermediate substituted benzopyran-2-one chalcones and were characterized using spectral analysis. Compounds were docked with receptor DNA Gyrase B (PDB code: 5L3J) to know its interaction and binding energy; ranges -3.38 to -2.15 kcal/mol. Further these compounds were tested for antibacterial activity using tube dilution method and MIC values were observed; ranges 3.12 to 25 µg/ml. Compound 3-(5-(m-tolyl)-4,5-dihydroisoxazol-3-yl)-2H-chromen-2-one (SR3) showed the best interaction with binding energy -3.38 kcal/mol and antimicrobial activity having MIC 3.12 µg/ml. GRAPHICAL ABSTRACT
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