Synthesis, Characterization and Antibacterial Evaluation of Some Substituted Pyrrolidines
Chemical Science International Journal · pp. 1–8 · Published 25 Oct 2016
10.9734/CSJI/2016/29734Abstract
Series of substituted heterocyclic Chalcones 3-aryl-1-(thiophen-2-yl) prop-2-en-1-one 1-9 had been prepared by using Claisen-Schmidt condensation. In addition, series of substituted Schiff bases N-arylidene benzylamines 10-13 were prepared by the condensation of benzyl amine with various substituted aromatic aldehydes. The reaction of the above materials occurred through 1,3-anionic cycloaddition of azallyl anion of Schiff bases which acted as a nucleophile to the double bond of chalcones afforded the corresponding heterocycles (pyrrolidines 14-24). Spectral data and some physical properties were used to support the structures of the new products. The antibacterial activity of some prepared compounds were tested through its Inhibition effects on two kinds of bacteria.
Cited by 2
Haitham L. Al-Hayali, Abdulwahhab J. Al-Hamadany, M. Al-Kattan · Tikrit Journal of Pure Science · 2023
M. Hussein, A. Al-Hamdany, Rana A. Saeed · Science Journal of University of Zakho · 2018
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