Synthesis, Characterisation and Evaluation of Azetidine-2-One Derivative
S. Ramachandran, S. Dheepika, M. Deepak, M. Duraiseelan, B. S. Chandru, M. Vijey Aanandhi
Journal of Pharmaceutical Research International · pp. 41–44 · Published 24 Mar 2022
10.9734/jpri/2022/v34i27A35992Abstract
Antibacterial, antifungal, anticancer, antitubercular, anti-HIV, analgesic, anti-inflammatory, and ulcerogenic activities have all been documented for azetidinone derivatives. The reaction of Schiff base((Z)-N (4-dimethylamino)benzylidene)pyrimidine-2-amine) with chloroacetyl chloride yielded a novel chemical called Azetdine-2-one derivative. Fourier Transform Infrared Spectroscopy and Proton Nuclear Magnetic Resonance Spectroscopy were used to confirm the chemical structures of the produced substances. The antimicrobial activity shows that the compound showed mild Antibacterial activity against Staphylococcus aureus and Escherichia coli.
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