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Research Article Open access CC BY 4.0

Synthesis, Characterisation and Antimicrobial Evaluations of Acetyloxyphenyl-1,2,3-triazole Linked Hexahydro Acridinediones

P. Shanmugasundaram, R. Sujatha, M. Vijey Aanandhi, V. Manivannan, M. Sivaraju

Journal of Pharmaceutical Research International · pp. 1–10 · Published 15 Feb 2022

10.9734/jpri/2022/v34i10B35559

Abstract

10-(2-hydroxyphenyl)-hexahydro acridinediones were treated with chloroacetyl choloride to give 10-(2-chloroacetyloxyphenyl) hexahydro acridinediones, which were treated with NaN3 in acetone followed by reaction with DMAD yielded 10-[2-(1-triazolo-4,5-dicarboxymethyl)acetyloxyphenyl]-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-  acridinediones.

Antimicrobial acetyloxyphenyl acridinediones triazoles triazolo-acridinedione

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