Synthesis and Characterization of Herbal Nano-suspensions and Evaluation of their In-vivo Antihypertensive Potential with Especial Focus on Piperine

Abstract

Poor aqueous solubility is the principle obstacle in accomplishing suitable oral bioavailability for huge proportion of drug composites in drug development todays. Nano-suspension is an emerging field of research in the scientific community to provide a new solution for poorly water-soluble active constituents. The objective of the nano-suspension is to reduce the drug particle size (100-200 nm) range, which enhance solubility and bioavailability of biopharmaceutical active compounds. Crude extract of Piper nigrum shows various biological activities but poor aqueous solubility so, there is a need to isolate the piperine from Piper nigrum and prepare its nano-suspension to reduce particle size and enhance its bioavailability. This review defines the principles behind nanosizing, the synthesis and characterization of piperine nano-suspension as well as the recent practice withapplication of such formulations in-vivo can be used as a better alternative to treat cardiovascular diseases with improved therapeutic efficacy compared to extract.