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Research Article Open access CC BY 4.0

Sub-Anesthetic Dose of Ketamine Improves Cognitive Function and Motor Responses in Wistar Rats

Precious Ojo Uahomo, Victor Tamunotonye Ibubeleye, Chidi Emmanuel Ezerioha, Oghenefego Michael Adheke

International Neuropsychiatric Disease Journal · pp. 29–42 · Published 2 Jun 2023

10.9734/indj/2023/v19i4380

Abstract

Background: The cognitive and motor effects of sub-anesthetic doses of ketamine remain controversial. The aim of this study was to investigate the effects of ketamine administration under anesthesia on cognitive function and motor responses in Wistar rats. Methods: Twenty-five Wistar rats were randomized into five groups of five rats each (n=5): group 1 (normal control), group 2 (1mg/kg ketamine), group 3 (2mg/kg ketamine), group 4 (3mg/kg ketamine) and group 5 (0.5ml/100g celecoxib). Treatment for each group lasted 3 weeks. Rats from each group were subjected to a total of nine (9) trials of cognitive-motor tests, including; the Barnes maze test (memory based on visual scenes), hand grip test (motor response to foreleg strength), rotarod test (coordination ability). The neurobehavioral ability displayed by the animals was recorded and analyzed using analysis of variance (ANOVA). Results: Observations from the cognitive function study showed a significant improvement (p<0.05) from week 1 to week 3. The quality of motor task performance also improved from week 1 to week 3 compared to control and celecoxib-treated groups. Conclusions: Sub-anesthetic doses of ketamine improved cognitive function and motor responses in Wistar rats.

Ketamine cognitive function motor responses chronic administration sub-anesthetic

References (34)

  1. 1 Synaptic Dysfunction in Depression: Potential Therapeutic Targets [DOI]
  2. 2 Glutamate and Schizophrenia: Phencyclidine, N‐Methyl‐d‐Aspartate Receptors, and Dopamine–Glutamate Interactions [DOI]
  3. 3 NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine [DOI]
  4. 4 Ketamine in Chronic Pain Management: An Evidence-Based Review [DOI]
  5. 5 Repetitive Mild Traumatic Brain Injury in a Mouse Model Produces Learning and Memory Deficits Accompanied by Histological Changes [DOI]
  6. 6 Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review [DOI]
  7. 7 Ketamine abuse potential and use disorder [DOI]
  8. 8 Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice [DOI]
  9. 9 Journey through the K-hole: Phenomenological aspects of ketamine use [DOI]
  10. 10 The Synthesis of Phencyclidine and Other 1-Arylcyclohexylamines [DOI]
  11. 11 A REVIEW OF KETAMINE ABUSE AND DIVERSION [DOI]
  12. 12 2012 Experimental and Clinical Psychopharmacology. [DOI]
  13. 13 Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex‐users with polydrug and non‐using controls [DOI]
  14. 14 The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity [DOI]
  15. 15 Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior [DOI]
  16. 16 Dose–response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity [DOI]
  17. 17 Ketamine, at a Dose that Disrupts Motor Behavior and Latent Inhibition, Enhances Prefrontal Cortex Synaptic Efficacy and Glutamate Release in the Nucleus Accumbens [DOI]
  18. 18 Ketamine: New Indications for an Old Drug [DOI]
  19. 19 Effects of Noncompetitive NMDA Receptor Blockade on Anterior Cingulate Cerebral Blood Flow in Volunteers with Schizophrenia [DOI]
  20. 20 Ketamine for chronic non-cancer pain [DOI]
  21. 21 Behavioral phenotyping of rodents.
  22. 22 Impaired Spatial Memory after Ketamine Administration in Chronic Low Doses [DOI]
  23. 23 Ketamine use disorder: preclinical, clinical, and neuroimaging evidence to support proposed mechanisms of actions [DOI]
  24. 24 Downregulation in the human and mice cerebella after ketamine versus ketamine plus ethanol treatment [DOI]
  25. 25 Effects of N-Methyl-D-aspartate (NMDA) antagonists ketamine, methoxetamine, and phencyclidine on the odor span test of working memory in rats. [DOI]
  26. 26 Anesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine, ketamine injection in dogs [DOI]
  27. 27 Craving for Ketamine and Its Relationship With Clinical Outcome Indicators in Males With Ketamine Use Disorder [DOI]
  28. 28 PHARMACOLOGIC EFFECTS OF CI-581, A NEW DISSOCIATIVE ANESTHETIC, IN MAN [DOI]
  29. 29 Intraventricular galanin impairs delayed nonmatching-to-sample performance in rats. [DOI]
  30. 30 Intraventricular galanin impairs delayed nonmatching-to-sample performance in rats. [DOI]
  31. 31 Neuropsychological Assessment of Learning and Memory in Rats Following Ketamine Exposure during Late Adolescence [DOI]
  32. 32 International Journal of Molecular Sciences [DOI]
  33. 33 Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. [DOI]
  34. 34 Drug Fact Sheet: Ketamine [DOI]

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