Study on the Hypolipidemic Effect of Moringa oleifera Seeds Based on Zebrafish  Hyperlipidemia Model

Tao Yuan; Xin-Yu Wen; Yue Chen; Yan Deng; Hong-Zhi Li; Yi Huang

doi:10.9734/aprj/2022/v10i1184

Research Article Open access CC BY 4.0

Study on the Hypolipidemic Effect of Moringa oleifera Seeds Based on Zebrafish Hyperlipidemia Model

Tao Yuan, Xin-Yu Wen, Yue Chen, Yan Deng, Hong-Zhi Li, Yi Huang

Asian Plant Research Journal · pp. 65–70 · Published 31 Oct 2022

10.9734/aprj/2022/v10i1184

Abstract

Objective: Investigated the hypolipidemic effect of alcoholic extract of Moringa oleifera seeds using the zebrafish hyperlipidemia model. Methods: Using 0.3% egg yolk solution to feed zebrafish larval to construct the hyperlipidemia model. These larval fish in the model were treated with an extract of Moringa oleifera seeds for 2 days. Then, the tail vessels were observed after oil red O staining, and the accumulated optical density of lipids was analyzed. The body length, triglyceride (TG), and cholesterol (TC) levels were measured. Result: The accumulated optical density of lipids in the tail vessels of larval fish fed with 0.3% egg yolk was significantly higher than that of the blank group. The contents of TG and TC were also increased, indicating that the hyperlipidemia model was successfully established. After treatment with different concentrations of Moringa oleifera seed extract (10 μg/ml, 15 μg/ml, and 20 μg/ml), the staining attachment surface of vascular oil red O in the tail of hyperlipidemic zebrafish was significantly reduced by 42.8%, 63.3%, and 80.6% respectively. TG was reduced by 9.89%, 20.41%, and 26.40%. TC was reduced by 9.85%, 23.93%, and 33.80%. The data of each group were statistically significant (P<0.01). Conclusion: Moringa seeds had a significant hypolipidemic effect on zebrafish and had no significant effect on the skeletal growth length of zebrafish.

Zebrafish hyperlipidemia Moringa oleifera seeds hypolipidemia

References (4)

1 Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats [DOI]
2 Effect and mechanism of ursolic acid in non-alcoholic fatty liver disease based on zebrafish model [DOI]
3 Extraction of Functional Components from Moringa oleifera and Development of Moringa oleifera-Based Products
4 International Journal of Molecular Sciences [DOI]

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Tao Yuan, Xin-Yu Wen, Yue Chen, Yan Deng, Hong-Zhi Li, Yi Huang (2022). Study on the Hypolipidemic Effect of Moringa oleifera Seeds Based on Zebrafish Hyperlipidemia Model. Asian Plant Research Journal , 65–70. https://doi.org/10.9734/aprj/2022/v10i1184

Affiliations

Tao Yuan — School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan-621010, China.
Xin-Yu Wen — School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan-621010, China.
Yue Chen — School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan-621010, China.
Yan Deng — School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan-621010, China.
Hong-Zhi Li — School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan-621010, China.
Yi Huang — School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan-621010, China.

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