Skip to content
Research Article Open access CC BY 3.0

Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Polymorphism in Egyptian Patients with Coronary Artery Disease

A. F. Abdel-Aziz, Afaf Elsaid, Rehab Elmougy, Ayman Abd-Al-Samad, A. M. Elwaseef

International Journal of Biochemistry Research & Review · pp. 106–119 · Published 17 Oct 2012

10.9734/IJBCRR/2012/1622

Abstract

Angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to coronary artery disease (CAD) and also with the lipid profile in different populations. One hundred and eight Egyptian patients with CAD and one hundred forty three unrelated healthy subjects were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD as well as its association with hypertension in the patients. Serum levels of lipoprotein (a), Lp (a), and interleukin-6 (IL-6) were estimated in the patients as well as in the healthy subjects. Increased frequency of D allele and DD genotype as well as decreased frequency of I allele and ID genotype were found in CAD patients compared to healthy subjects (P = .004, OR= 0.419, 95% CI (.2 - .8), for DD genotype), (P = .008, OR= 0.475, 95% CI (0.27-0.84), for D allele). Higher levels of both Lp (a) and IL-6 were observed in CAD patients compared to control subjects (P = .0012, P = .0346, respectively). No association was observed in ACE gene polymorphism with diabetes mellitus or hyperlipidemia. However, there is a trend for DD genotype to develop more hypertension than ID genotype (P=0.08, OR=2.88). In conclusion, theI/D polymorphism of the ACE gene (carrying the D allele) is an independent risk factor for CAD in the studied Egyptian population.

ACE I/D polymorphism coronary artery disease hyperlipidemia hypertension

References (32)

  1. 1 Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction [DOI]
  2. 2 PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1) [DOI]
  3. 3 RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population [DOI]
  4. 4 The Autopsy in Clinical Medicine [DOI]
  5. 5 Influence of the ACE Gene Insertion/Deletion Polymorphism on Insulin Sensitivity and Impaired Glucose Tolerance in Healthy Subjects [DOI]
  6. 6 Relationship Between Angiotensin-converting Enzyme Insertion/Deletion Gene Polymorphism and Systemic Lupus Erythematosus/Lupus Nephritis: A Systematic Review and Metaanalysis [DOI]
  7. 7 Renin–angiotensin system genes polymorphism in Egyptians with premature coronary artery disease [DOI]
  8. 8 Association of angiotensin-converting enzyme insertion/deletion polymorphism with obesity, cardiovascular risk factors and exercise-mediated changes in Korean women [DOI]
  9. 9 Renin-angiotensin system: Genes to bedside [DOI]
  10. 10 Efficacy and tolerability of combined treatment with l-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus [DOI]
  11. 11 Association between lipoprotein(a) levels, apo(a) isoforms and family history of premature CAD in young Asian Indians [DOI]
  12. 12 Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene in Coronary Artery Disease in Southern Turkey [DOI]
  13. 13 Lipoprotein (A): Better assessor of coronary heart disease risk in south Indian population [DOI]
  14. 14 High prevalence of ACE DD genotype among north Indian end stage renal disease patients [DOI]
  15. 15 Association of angiotensin-converting enzyme I/D polymorphism with heart failure: a meta-analysis [DOI]
  16. 16 Angiotensin converting enzyme DD genotype not associated with increased risk of coronary artery disease in the Iranian population [DOI]
  17. 17 Serum interleukin-6 concentration reflects the extent of asymptomatic left ventricular dysfunction and predicts progression to heart failure in patients with stable coronary artery disease [DOI]
  18. 18 Plasma Lipoprotein (a) levels in patients with untreated essential hypertension
  19. 19 The relationship of ACE and CETP gene polymorphisms with cardiovascular disease in a cohort of Asian Indian patients with and those without type 2 diabetes [DOI]
  20. 20 Angiotensin-I-converting enzyme (ACE) insertion/deletion polymorphism in Mexican patients with coronary artery disease. Association with the disease but not with lipid levels [DOI]
  21. 21 Interleukin-6 in clinical medicine [DOI]
  22. 22 Lipoprotein(a) associated with coronary artery disease in older women: age and gender analysis [DOI]
  23. 23 DNA variants, plasma levels and variability of Interleukin-6 in myocardial infarction survivors: Results from the AIRGENE study [DOI]
  24. 24 DD ACE gene polymorphism is associated with increased coronary artery endothelial dysfunction: the PREFACE trial: Figure 1 [DOI]
  25. 25 The association of ACE gene D/I polymorphism with cardiovascular risk factors in a population from Rio de Janeiro [DOI]
  26. 26 Lipoprotein profile in Arabian type 2 diabetic patients. Relationship to coronary artery diseases [DOI]
  27. 27 Effect of angiotensin converting enzyme gene I/D polymorphism in patients with metabolic syndrome in North Indian population.
  28. 28 Angiotensin Converting Enzyme Gene I/D polymorphism correlates with complications in HCV infected Egyptian Patients
  29. 29 Angiotensin II Enhances Lipid Peroxidation of Low-Density Lipoprotein [DOI]
  30. 30 Correlation between serum lipoprotein (a) and angiographic coronary artery disease in non‐insulin‐dependent diabetes mellitus [DOI]
  31. 31 ELEVATED LIPOPROTEIN (a) LEVELS SEEN IN PATIENTS WITH CORONARY ARTERY DISEASE
  32. 32 Relationship Between the ACE Gene Polymorphism and Angiographic Coronary Artery Disease

Cited by 12

Synergistic effect of ACE and AGT genes in coronary artery disease

Ibrahim H. Borai, Nahla S. Hassan, Olfat G. Shaker · Beni-Suef University Journal of Basic and Applied Sciences · 2018

Polymorphism and synergism of angiotensin-converting enzyme ( ACE ) and plasminogen activator inhibitor-1 ( PAI-1 ) genes in coronary artery disease

Maryam Sakhteh, Behzad Poopak, Naser Amirizadeh · Journal of the Renin-Angiotensin-Aldosterone System · 2014

Showing 6 of 12 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

75

Page views

0

PDF downloads

46

Outbound clicks

12

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.