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Research Article Open access CC BY 4.0

Study of Thyroid Dysfunction in Association with Infertility

Padmini Prakash Habbu, Abdul Kayyum Shaikh

International Journal of Biochemistry Research & Review · pp. 1–6 · Published 18 Mar 2016

10.9734/IJBCRR/2016/24926

Abstract

Aims: To evaluate the relation of female infertility to thyroid dysfunction. Study Design: This is a descriptive, hospital-based study. Place and Duration of Study: The present study was carried out in the department of Biochemistry in collaboration with the Gynae and Obst department, Ashwini Rural Medical College, Hospital and research centre Solapur. Over the period of 6 month from August 2015 to January 2016.  Methodology: The study group included 60 cases among which 48 women were having primary infertility & 12 women had secondary infertility, while control group included 40 fertile euthyroid women. Serum T3, T4 and TSH estimation was done by Enzyme linked fluorescent assay on mini VIDAS. Results: In hyperthyroid FT3 level 21.33±7.31 pmol/L, in hypothyroid 3.52±1.20 pmol/L (P value < 0.001, i.e., highly significant), and in euthyroid 4.19±0.58 pmol/L (P value ˃ 0.05, i.e., not significant), 4.17±0.80 pmol/L, when compared with control. FT4 level was 52.7±4.52 pmol/L in hyperthyroid (p value ˂0.001. i.e. highly significant), while in hypothyroid 9.80±5.5 pmol/L, and in euthyroid 13.82±3.48 pmol/L (P value ˃ 0.05, i.e. not significant), 14.63±2.85 pmol/L, when compared with control. Serum TSH level in hyperthyroid was 0.22±0.10 µIU/ml, in hypothyroid 21.98±19.86 µIU/ml (P value ˂ 0.001, i.e. significant), 2.61±1.24 µIU/ml in euthyroid (P value ˃ 0.05, i.e. not significant); 2.72±1.51 µIU/ml when compared with control. Conclusion: Thyroid hormones play an important role in normal reproductive function, both through direct effects on the ovaries and also indirectly by multiple interactions with other sex hormones. Therefore, thyroid dysfunction can lead to menstrual irregularities and, thus, finally to infertility.

Thyroid dysfunction infertility hypothyroidism hyperthyroidism

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Cited by 8

Effects of hypothyroidism in Indian women of reproductive age group – A review article

Selvi Kumar, Pushpa Kotur · Indian Journal of Obstetrics and Gynecology Research · 2020

Subclinical hypothyroidism among infertile women at a tertiary hospital in South-West Nigeria

Olusoji E Jagun, Babatunde A Andu, Olatunbosun O Olawale · African Health Sciences · 2022

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