Study of the Antibacterial Activity of a New Prolonged-Release Dental Dosage form Containing Doxycycline and Lidocaine

Abstract

A dental infection, Gingivitis is a common and mild form of gum disease (periodontal disease) that causes irritation, redness and swelling (inflammation) of your gums. Gingivitis is able to escort to much more grave gum disease (periodontitis) and eventual tooth loss. To treat dental problems painkillers along with antibiotics and some dental paints are the commonly prescribed But the common side effects of most of the painkillers are hyperacidity and gastric irritation most antibiotics due to slow onset of action and hepatic “first-pass” effect fail to produce prompt and prolong actions. Moreover, most of the dental formulations are washed out by saliva within a few hours of application. Hypothesis of the study is that if a soft moldable gummy material containing analgesic as well as antibiotic drugs is attached to an offending tooth and sustained drug release occurs from it, a extended local action of the drugs is achieved. Ethyl cellulose, gum tragacanth, hydroxyl propyl cellulose, PEG-400 and carbopol 934 were used to prepare denticap containing Doxycycline hydrate and lidocaine.