Solvent free Synthesis of 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl] Acetohydrazide Derivatives as Novel Antimicrobial and Antitumor Agents
J. Paveendra, H. M. Vagdevi, Dyamanna Thippeswamy, Yanjerappa Arthobha Nayaka
Journal of Pharmaceutical Research International · pp. 36–45 · Published 23 May 2023
10.9734/jpri/2023/v35i137368Abstract
In pursuit of designing novel chemical entities with antitumor and antimicrobial activities, 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl]acetohydrazidederivatives have been synthesized as a scaffold of a series of amine derivatives, these analogs were on reductive amination with solvent free condition. All the synthesized compounds were assessed for antibacterial, antifungal, and antitumor activities against standard strains. The compounds 3a, 3b and 3g showed highest degree of inhibition against A. flavus and compounds 3a, 3b, 3d and 3h Showed highest degree of inhibition against C. albicans, compounds 3a,3e and 3g has shown the encouraging antibacterial activityresults against E. coli and compounds 3a, 3b and 3h exhibited a promising activity against B. subtilis. Compounds 3a, 3b and 3c exhibited promising antitumor activity.
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