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Research Article Open access CC BY 3.0

Sildenafil Determination by Using UPLC in Different Italian Viagra Tablets

Nicola Giarretta, Maria C. Mezzacapo, Antonella M. A. Di Giuseppe, Nicola Landi, Martina Lippert, Antimo Di Maro

International Journal of Biochemistry Research & Review · pp. 607–614 · Published 14 Aug 2014

10.9734/IJBCRR/2014/12821

Abstract

Aims: The introduction of generics drugs has brought the need for more control of their quality and purity. In Italy from June 23, 2013 the Pfizer® has no longer the patent for the Viagra’s production and other industries produce equivalent products containing Sildenafil citrate. Study design: Thus, in this work, the chemical profiles of both Viagra Italian Pfizer® and 3 Italian commercial Sildenafil citrate tables (generic pharmaceutical manufacturers) for male erectile dysfunction were obtained by using UltraPerformanceLiquid Chromatography (UPLC). Methodology: UPLC methodology was successfully used for the assay of Sildenafil citrate in different products in Italy which are under the cover of alternative systems of medicine. Results: The results show that: i) the chromatographic profiles obtained from Italian Sildenafil citrate tablets are identical and not present other active pharmaceutical ingredients; ii) the commercial samples have a quantity of Sildenafil citrate comparable with the corresponding labelled amounts. Conclusion: The UPLC method can be used for determination of Sildenafil citrate tables marketed by generic pharmaceutical manufacturers in Italy.

Chemical profile UPLC pharmaceutical preparations sildenafil stress testing Viagra

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