Sickle Cell Disease and Severity of Malaria

Abstract

Background: The relationship between sickle cell disease and malaria remains controversial and the hypothesis that sickle cell disease protects against malaria is widespread. Methodology: A descriptive and retrospective study over a two-year period (2014-2016) was conducted in pediatric departments of the National Hospital of Niamey (NHN). The objective is to assess the relative risk between sickle cell disease and the severity of malaria. Results: Nine hundred and seventy four (974) patients infected with Plasmodium falciparum were included in this study. Thirteen point twenty four percent (129/974) of patients had sickle cell disease, of which 93.8% (121/129) had SS form and 6.2% (8/129) SC form. Seventy-nine point eight percent (103/129) of sickle cell patients had severe malaria (RR = 0.9, p = 0.17). Ninety six point one percent (99/103) of patients with severe malaria were homozygous SS versus 3.8% (4/103) who were heterozygous SC (RR = 0.6, p = 0.05). Eleven point forty three percent (4/35) of sickle cell patients died of malaria (RR = 0.1, p = 0.4). Seventy-five percent (3/4) of the deceased sickle cell were homozygous SS versus 25% (1/4) who were heterozygous SC (RR = 5, p = 0.2). Conclusion: Heterozygous sickle cell patients have less severe malaria than homozygotes. Malaria is more severe and more lethal in homozygous sickle cell patients. A strategy for the prevention of sickle cell malaria should be developed during periods of high transmission.