Sequential Strain Improvement of Cordyceps militaris
L. B. Laxmikanth Rathod, Shaik Muzammil Pasha, Anju Rajan, Madhavi ., Chand Pasha
Journal of Advances in Microbiology · pp. 13–20 · Published 27 Feb 2023
10.9734/jamb/2023/v23i3711Abstract
Aim: As a highly valued fungus, Cordyceps militaris has been widely used all over the world. Although the wild resources of C. militaris are limited, the fruiting bodies of C. militaris have been successfully cultivated on a large-scale with limited Cordycepin production. However, the high-frequency degeneration of C. militaris during subculture and preservation seriously limits the development of the C. militaris industry. Methods and Results: In this study, three different techniques for strain improvement viz., protoplast fusion, UV irradiation and chemical mutagenesis were assessed for improved biomass and cordycepin production. Conclusion: It was observed that the fusant subsequently mutated were stable for many generation and yielding improved biomass and Cordycepin. It was found that fusants after mutagenesis will be genetically stable and this methodology can be used for strain improvement of genetically unstable microorganisms.
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Cited by 6
Subrata Giri, Prakash Pradhan · Frontiers in Entomopathogenic Fungi · 2026
Rubi Kumari, Nayna Mukherjee, Aryan Sharma · Biosciences Biotechnology Research Asia · 2024
Shaik Muzammil Pasha, Anju Nitin Rajan, Laxmikant Rathod · Asian Journal of Biological Sciences · 2024
Showing 3 of 6 known citations — external sources report more than can currently be individually listed.
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