Safety of Repeated Twice-daily 30 Minutes of 2 mA tDCS in Depressed Patients
Ulrich Palm, Bianka Leitner, Wolfgang Strube, Alkomiet Hasan, Frank Padberg
International Neuropsychiatric Disease Journal · pp. 168–171 · Published 1 Sep 2015
10.9734/INDJ/2015/19719Abstract
Aims: Transcranial direct stimulation (tDCS) is recently discussed as a therapeutic option in psychiatric disorders and has brought preliminary convincing results in the treatment of depressive disorders. Hence the optimal stimulation parameters still remain elusive as randomized controlled trials over last years used divergent stimulation protocols and duration, frequency, and current strength still have to be standardized. Presentation of Cases: In this case series we report on the safety of twice daily 30 min tDCS at 2 mA over longer stimulation periods and interval treatment. Six patients (mean age 59.5±22.3, age range 29-87 years) with major depressive disorder received 20 to 31 tDCS treatments within 14 and 50 days, including acute treatment series and maintenance treatment. In the majority of participants, tDCS exerted antidepressant effects. tDCS was well tolerated and there were no clinically relevant adverse events. Discussion: These preliminary data suggest safety and tolerability of twice-daily 30 min tDCS even in a prolonged protocol. Conclusion: tDCS is gaining growing importance as a therapeutic tool in neuropsychiatric disorders and seems to be safe even when applied extensively.
Cited by 10
Ulrich Palm, Alkomiet Hasan, Wolfgang Strube · European Archives of Psychiatry and Clinical Neuroscience · 2016
Ulrich Palm, Stephan Goerigk, Beatrice Kirsch · Brain Stimulation · 2019
Mirjam Handrack, Ulrich Voderholzer, Caroline Schwartz · Brain Stimulation · 2018
Wolfgang Strube, Beatrice Kirsch, Frank Padberg · Journal of Clinical Psychopharmacology · 2016
Ulrich Palm, Bianka Leitner, Beatrice Kirsch · Neurocase · 2017
Eva Mezger, Andre R. Brunoni, Alkomiet Hasan · Neurocase · 2020
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri, Mehdi Ahmadi · Journal of Psychiatric Research · 2021
Anna Katharina Kurzeck, Esther Dechantsreiter, Anja Wilkening · Brain Sciences · 2021
Rémi Moirand, Laetitia Imbert, Frédéric Haesebaert · Journal of Clinical Medicine · 2022
Nora Behler, Bianka Leitner, Eva Mezger · Frontiers in Behavioral Neuroscience · 2018
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