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Research Article Open access CC BY 3.0

rs11655505 (c.-2265 C/T) Variant in BRCA1 Promoter is not associated with Breast Cancer Risk in South India

Tarique N Hasan, B. Leena Grace, Gowhar Shafi, Rabbani Syed

Journal of Advances in Medicine and Medical Research · pp. 153–161 · Published 21 Dec 2012

10.9734/BJMMR/2013/2082

Abstract

Aim: Breast cancer is leading cause of cancer deaths in women, globally. Recently a study on a Chinese population suggested that there is a protective role of rs11655505 (c.-2265 C/T) in the BRCA1 promoter whereas, the same in Caucasian population showed no effect on breast cancer prevalence. This study was undertaken to find out, if there is any association between rs11655505 (c.-2265 C/T) and breast cancer in an Indian population. Methodology: Blood samples were collected from 352 female breast cancer patients and 380 healthy women of age range 18-68 years. DNA was extracted from blood through standard salting out procedure. All the DNA samples were genotyped by using TaqMan® SNP Genotyping Assays. Data obtained was analyzed statistically to find out the possible association between the variation and predisposition of breast cancer Results: No association was found between rs11655505 and breast cancer occurrences in familial (p=0.61), non-familial (p=0.45) and premenopausal patients (p=0.52) groups. Menopausal group had a significant association (p=0.01) with studied SNP. Conclusion: Present study failed to confirm an association between of rs11655505 and breast cancer. Larger studies are required to consolidate if there is any little association of rs11655505 with breast cancer risk.

BRCA1 promoter rs11655505 breast cancer

References (25)

  1. 1 A simple salting out procedure for extracting DNA from human nucleated cells [DOI]
  2. 2 Cancer Incidence in Five Continents [DOI]
  3. 3 Cancer Incidence in Five Continents [DOI]
  4. 4 Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2 [DOI]
  5. 5 Allelic discrimination using fluorogenic probes and the 5′ nuclease assay [DOI]
  6. 6 BRCA1Mutations in Women Attending Clinics That Evaluate the Risk of Breast Cancer [DOI]
  7. 7 Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression [DOI]
  8. 8 Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations [DOI]
  9. 9 Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens [DOI]
  10. 10 Changing cancer incidence in Kampala, Uganda, 1991–2006 [DOI]
  11. 11 Functional Haplotypes in the Promoter of Matrix Metalloproteinase-2 Predict Risk of the Occurrence and Metastasis of Esophageal Cancer [DOI]
  12. 12 BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles [DOI]
  13. 13 Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2 [DOI]
  14. 14 BRCA1 and BRCA2 in Indian breast cancer patients [DOI]
  15. 15 BRCA1 and BRCA2 germline mutation analysis among Indian women from south India: identification of four novel mutations and high-frequency occurrence of 185delAG mutation [DOI]
  16. 16 Changing trends in incidence of breast cancer: Indian scenario [DOI]
  17. 17 Disease Phenotypes and Gender Association of FCRL3 Single-Nucleotide Polymorphism −169T/C in Taiwanese Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis [DOI]
  18. 18 Gene expression profiling in women with breast cancer in a Saudi population [DOI]
  19. 19 BRCA1 MUTATIONS IN WOMEN ATTENDING CLINICS THAT EVALUATE THE RISK OF BREAST CANCER
  20. 20 A Haplotype-Based Case-Control Study of BRCA1 and Sporadic Breast Cancer Risk [DOI]
  21. 21 Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women [DOI]
  22. 22 BRCA1 and TP53 mutation spectrum of breast carcinoma in an ethnic population of Kashmir, an emerging high-risk area [DOI]
  23. 23 A BRCA1 promoter variant (rs11655505) and breast cancer risk: Table 1 [DOI]
  24. 24 A novel BRCA1 mutation in an Indian family with hereditary breast/ovarian cancer [DOI]
  25. 25 Genetic Variation in IL-6 and TNF-α Genes with Risk of Breast Cancer in a Saudi Population-based Case-Control Study [DOI]

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