Role Played by Biochemical and Hematological Parameters in the Prediction of Cardiovascular Risk
W. K. T. Nuwanthika, D. I. K. Welivitigoda, S. P. N. N. Senadeera, D. U. Kottahachchi, C. B. Ranaweera, N. Wijesinghe
Asian Journal of Research in Biochemistry · pp. 7–17 · Published 11 Mar 2024
10.9734/ajrb/2024/v14i2278Abstract
Introduction: The term “cardiovascular diseases” (CVDs) refers to any disease affecting the heart or blood vessels. CVDs are the most common cause of death worldwide and the most responsible reason for 10% of deaths in the early 20th century. These CVDs can emerge as myocardial infarction or ischemic heart disease, stroke, and congestive heart failure. For diagnosing CVDs, physical, radiological investigations, and laboratory investigations for cardiac enzymes and lipid profile are used. In clinical practices, cardiovascular risk prediction models are very important in the identification, prevention, and staging of the severity of CVDs. Framingham Risk Score-coronary heart disease, Framingham Risk Score-cardiovascular disease, QRESEARCH-cardiovascular risk algorithm, Joint British Society risk-calculator-3, WHO/ISH CVD risk prediction charts, and Atherosclerotic Cardiovascular Disease risk-estimator are some of the available CVD risk estimators. However, many of these estimators can be used only to evaluate individuals more than 40 years and to assess the risk for 10-years. Therefore, new risk estimators are needed to overcome the deficiencies of the available risk estimators. Research have been done in novel directions; on ratios of routinely performing hematological and biochemical laboratory parameters such as Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), and Aspartate aminotransferase to Alanine aminotransferase ratio (AST/ALT). The outcomes indicate a relationship between the above-said ratios and the risk for CVDs. Conclusion: On such grounds, this review describes the importance of developing a CVD risk estimator by amalgamating some of the biochemical and hematological parameters, including NLR, PLR, and AST/ALT ratios, aiming to overcome the existing shortcomings.
References (56)
- 1 Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 [DOI]
- 2 Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study [DOI]
- 3 Prediction of Lifetime Risk for Cardiovascular Disease by Risk Factor Burden at 50 Years of Age [DOI]
- 4 Neutrophil-to-lymphocyte ratio, past, present and future perspectives [DOI]
- 5 What is the normal value of the neutrophil-to-lymphocyte ratio? [DOI]
- 6 A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes [DOI]
- 7 Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study [DOI]
- 8 Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis [DOI]
- 9 An independent and external validation of QRISK2 cardiovascular disease risk score: a prospective open cohort study [DOI]
- 10 The AST/ALT ratio as an indicator of cirrhosis in patients with PBC [DOI]
- 11 Red blood cell distribution width and cardiovascular diseases. [DOI]
- 12 Lipid parameters for measuring risk of cardiovascular disease [DOI]
- 13 Neutrophilia Predicts Death and Heart Failure After Myocardial Infarction [DOI]
- 14 Patterns and causes of liver involvement in acute dengue infection [DOI]
- 15 Platelet to Lymphocyte Ratio in Cardiovascular Diseases: A Systematic Review [DOI]
- 16 Comparison of the Framingham Risk Score, SCORE and WHO/ISH cardiovascular risk prediction models in an Asian population [DOI]
- 17 Relative lymphocyte count: A prognostic indicator of mortality in elderly patients with congestive heart failure [DOI]
- 18 Comparison of different cardiovascular risk score calculators for cardiovascular risk prediction and guideline recommended statin uses [DOI]
- 19 Evaluation of complete blood count parameters in cardiovascular diseases: An early indicator of prognosis? [DOI]
- 20 Hypertension Is a Risk Factor for Several Types of Heart Disease: Review of Prospective Studies [DOI]
- 21 Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are Predictors of Heart Failure [DOI]
- 22 Platelet count is associated with cardiovascular disease, cancer and mortality: A population-based cohort study [DOI]
- 23 Usefulness of Neutrophil-to-Lymphocyte Ratio in Risk Stratification of Patients With Advanced Heart Failure [DOI]
- 24 Aspartate aminotransferase and cardiovascular disease—a narrative review [DOI]
- 25 Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study [DOI]
- 26 Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up [DOI]
- 27 Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke [DOI]
- 28 The prognostic role of platelet-to-lymphocyte ratio in patients with acute heart failure: A cohort study [DOI]
- 29 Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography [DOI]
- 30 The value of aspartate aminotransferase and alanine aminotransferase in cardiovascular disease risk assessment [DOI]
- 31 Combined Usefulness of the Platelet-to-Lymphocyte Ratio and the Neutrophil-to-Lymphocyte Ratio in Predicting the Long-Term Adverse Events in Patients Who Have Undergone Percutaneous Coronary Intervention with a Drug-Eluting Stent [DOI]
- 32 AST/ALT ratio predicts the functional severity of chronic heart failure with reduced left ventricular ejection fraction [DOI]
- 33 Preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with major adverse cardiovascular and cerebrovascular events in coronary heart disease patients undergoing non-cardiac surgery [DOI]
- 34 Cardiovascular risk assessment tools in Asia
- 35 Racial/Ethnic Differences in Hypertension Prevalence, Treatment, and Control for Outpatients in Northern California 2010–2012 [DOI]
- 36 Non‐alcoholic fatty liver disease is associated with cardiovascular disease risk markers [DOI]
- 37 Elevated liver enzymes and cardiovascular mortality: a systematic review and dose–response meta-analysis of more than one million participants [DOI]
- 38 Prognostic value of neutrophil-to-lymphocyte ratio in pulmonary arterial hypertension [DOI]
- 39 Clinical utility of red blood cell distribution width in inflammatory and non‐inflammatory joint diseases [DOI]
- 40 Perfil lipídico e fatores de risco para doenças cardiovasculares em estudantes de medicina [DOI]
- 41 Severe Neutropenia in Dengue Patients: Prevalence and Significance [DOI]
- 42 The association between AST/ALT ratio and all-cause and cardiovascular mortality in patients with hypertension [DOI]
- 43 Knowledge of risk factors for diabetes or cardiovascular disease (CVD) is poor among individuals with risk factors for CVD [DOI]
- 44 INTERPRETATION OF THE COMPLETE BLOOD COUNT [DOI]
- 45 Risk estimates of cardiovascular diseases in a Sri Lankan community [DOI]
- 46 Increased neutrophil to lymphocyte ratio predicts myocardial injury in patients undergoing non-cardiac surgery [DOI]
- 47 Epidemiologic studies targeting primary cardiovascular disease prevention in South Asia [DOI]
- 48 Orientation diagnostique devant une lymphopénie [DOI]
- 49 A young woman with rigors and abdominal pain [DOI]
- 50 Development and Distortion of Malaysian Public- Private Partnerships: Patronage, Privatised Profits and Pitfalls DOI: 10.1111/j.1467- 8500.2009.00655.x [DOI]
- 51 Lipids in Atherosclerosis: Pathophysiology and the Role of Calculated Lipid Indices in Assessing Cardiovascular Risk in Patients with Hyperlipidemia [DOI]
- 52 Red Blood Cell Distribution Width as Novel Biomarker in Cardiovascular Diseases: A Literature Review [DOI]
- 53 Cost analysis of treating cardiovascular diseases in a super-specialty hospital [DOI]
- 54 Evaluation of cardiovascular diseases risk calculators for CVDs prevention and management: scoping review [DOI]
- 55 Absolute lymphocyte count as a predictor of mortality and readmission in heart failure hospitalization [DOI]
- 56 High AST/ALT Ratio Is Associated with Cardiac Involvement in Acute COVID-19 Patients [DOI]
Cited by 2
S. P. N. N. Senadeera, D. S. H. S. Peiris, D. T. K. Fernando, D. U. Kottahachchi, C. B. Ranaweera · Cardiology and Angiology: An International Journal · 2024
Showing 1 of 2 known citations — external sources report more than can currently be individually listed.
Article metrics
Real usage data collected on this platform.
63
Page views
0
PDF downloads
26
Outbound clicks
2
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.