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Research Article Open access CC BY 4.0

Role of Intestinal Parasitic Infection in Stunting

Forman Erwin Siagian

South Asian Journal of Research in Microbiology · pp. 41–50 · Published 27 Apr 2023

10.9734/sajrm/2023/v15i2285

Abstract

Aim: To review recent findings in the context of the relation between intestinal parasitic infection (IPI) induce the host’s chronic immune activation and systemic inflammation that contributes to stunting. Discussion: To some extent, based on the parasite species (with the account of the condition of co-infections), combined with its timing (when was the initial infection took place), the duration of the disease, its intensity, and also must be considered the patho-physiology effects, can cause serious effect to their host. Prolonged IPI contributes to the formation of stunting. Active IPI can cause direct dysregulation of growth factors which are important for prenatal and postnatal growth. Furthermore, IPI opens the door for the entry of secondary infections, bacterial and viral, and allowed them to established definite co-infection which can cause prolonged inflammation, locally and systematically. Several potential interrelated mechanistic routes also could be connected through the host’s imbalanced nutritional status, possible environmental enteric dysfunction (EED) due to persistent IPI and prolonged inflammation, hormonal derangement and perhaps also due to metabolic disturbances, immune dynamics, the consequences of  definite anaemia, changed microbiota composition, and also changes in epigenetic signature. Conclusion:  Persistent and prolonged IPI induced both chronic immune activation and systemic inflammation that contributes to the formation of stunting, directly and indirectly.

Helminths protozoan co-infection children nutrition environmental enteric dysfunction microbiota composition

References (55)

  1. 1 Childhood stunting: a global perspective [DOI]
  2. 2 The stunting syndrome in developing countries [DOI]
  3. 3 The gut microbiome: Relationships with disease and opportunities for therapy [DOI]
  4. 4 Regulation of the host immune system by helminth parasites [DOI]
  5. 5 Stunting in childhood: an overview of global burden, trends, determinants, and drivers of decline [DOI]
  6. 6 Child Stunting is Associated with Low Circulating Essential Amino Acids [DOI]
  7. 7 The Role of the Immune System in Metabolic Health and Disease [DOI]
  8. 8 Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance [DOI]
  9. 9 Environmental enteric dysfunction pathways and child stunting: A systematic review [DOI]
  10. 10 Preventing environmental enteric dysfunction through improved water, sanitation and hygiene: an opportunity for stunting reduction in developing countries [DOI]
  11. 11 Parasite-Microbiota Interactions With the Vertebrate Gut: Synthesis Through an Ecological Lens [DOI]
  12. 12 Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation [DOI]
  13. 13 Effects of GH/IGF axis on bone and cartilage [DOI]
  14. 14 Environmental enteric dysfunction and child stunting [DOI]
  15. 15 How countries can reduce child stunting at scale: lessons from exemplar countries [DOI]
  16. 16 Tradeoffs between immune function and childhood growth among Amazonian forager-horticulturalists [DOI]
  17. 17 Feast or famine: the host-pathogen battle over amino acids [DOI]
  18. 18 Complementary Feeding: Pitfalls for Health Outcomes [DOI]
  19. 19 Stunting Was Associated with Reported Morbidity, Parental Education and Socioeconomic Status in 0.5–12-Year-Old Indonesian Children [DOI]
  20. 20 Biochemistry, Essential Amino Acids
  21. 21 The Effects of Nutrition on Linear Growth [DOI]
  22. 22 Impact of Stunting on Development of Children between 1-3 Years of Age [DOI]
  23. 23 Helminth infections and intestinal inflammation [DOI]
  24. 24 Anti-cancer effects of vitamin C revisited [DOI]
  25. 25 Parasites and steroid hormones: corticosteroid and sex steroid synthesis, their role in the parasite physiology and development [DOI]
  26. 26 Suppression of inflammation by helminths: a role for the gut microbiota? [DOI]
  27. 27 Parasites, nutrition, immune responses and biology of metabolic tissues [DOI]
  28. 28 IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection [DOI]
  29. 29 Understanding multifactorial drivers of child stunting reduction in Exemplar countries: a mixed-methods approach [DOI]
  30. 30 The high prevalence of intestinal parasitic infections is associated with stunting among children aged 6–59 months in Boricha Woreda, Southern Ethiopia: a cross-sectional study [DOI]
  31. 31 Amino Acid Metabolism in Apicomplexan Parasites [DOI]
  32. 32 The crown joules: energetics, ecology, and evolution in humans and other primates [DOI]
  33. 33 Getting enough energy for immunity [DOI]
  34. 34 Linear growth faltering and the role of weight attainment: Prospective analysis of young children recovering from severe wasting in Niger [DOI]
  35. 35 Intestinal parasites: Associations with intestinal and systemic inflammation [DOI]
  36. 36 Evidence for height and immune function trade-offs among preadolescents in a high pathogen population [DOI]
  37. 37 Environmental Influences on Dietary Intake of Children and Adolescents [DOI]
  38. 38 Low Intake of Essential Amino Acids and Other Risk Factors of Stunting among Under-Five Children in Malang City, East Java, Indonesia [DOI]
  39. 39 Sex Steroids Effects on the Molting Process of the Helminth Human Parasite Trichinella spiralis [DOI]
  40. 40 Wasting and Stunting in Infants and Young Children as Risk Factors for Subsequent Stunting or Mortality: Longitudinal Analysis of Data from Malawi, South Africa, and Pakistan [DOI]
  41. 41 Prevalence and Risk Factors of Intestinal Parasitic Infection in Under-Five Children With Malnutrition: A Hospital Based Cross-Sectional Study [DOI]
  42. 42 Comparison of Cognitive Function in Children with Stunting and Children with Undernutrition with Normal Stature [DOI]
  43. 43 Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge [DOI]
  44. 44 Parasites and fungi as a threat for prenatal and postnatal human development.
  45. 45 Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children [DOI]
  46. 46 Helminth Mediated Attenuation of Systemic Inflammation and Microbial Translocation in Helminth-Diabetes Comorbidity [DOI]
  47. 47 Microbial Normal Flora: Its Existence And Their Contribution To Homeostasis [DOI]
  48. 48 Attributing diseases to multiple pathways: a causal-pie modeling approach [DOI]
  49. 49 Excellent image quality or superior dose conformity? [DOI]
  50. 50 Intestinal Microflora Vs Protozoan Parasites: From Interaction to Competition [DOI]
  51. 51 Infant and Young Child Feeding: Model chapter for textbooks for medical students and allied health professionals [DOI]
  52. 52 Importance of Maternal Nutrition in the First 1,000 Days of Life and Its Effects on Child Development: A Narrative Review [DOI]
  53. 53 Helminths and Bacterial Microbiota: The Interactions of Two of Humans’ “Old Friends” [DOI]
  54. 54 Sex—the most underappreciated variable in research: insights from helminth-infected hosts [DOI]
  55. 55 Do Intestinal Unicellular Parasites Have a Role in the Inflammatory and Redox Status among the Severely Obese? [DOI]

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