Role of Adiponectin and Serotonin in Development of Obesity and Therapeutic Implications

Abstract

Obesity is a major health concern worldwide as it provokes other health issues. The rise of obesity cases has started public concern as chronic obesity incidences are closely related to significantly shortened life expectancy. Coronary artery disease, hypertension, liver/biliary disease, osteoarthritis, strokes and type 2 diabetes are the common comorbidities which are closely associated with obesity. Adiponectin is the copious adipokine secreted by the adipose tissue in a human body. It is an anti-inflammatory and vasculoprotective cytokine whereas Serotonin, 5-hydroxytryptamine (5-HT) is a bio amine derived product of the amino acid tryptophan. Adiponectin and serotonin are observed to be the parts of the obesity by indirectly acting on the adipose tissues. The association of adiponectin and serotonin is based on the effect of adiponectin and serotonin on each other activity. Studies showed an elevation of serotonin may down-regulated the expression of adiponectin, which is normally seen in the case of obesity. Also, the factors affecting their activity vary from the molecular to the physical level.