Rivaroxaban: Compatibilty with Pharmaceutical Excipients using DSC and FTIR Spectrophotometry
Rama Rao Nadendla, J. Satynarayana, Jaya Krishna Burri
Journal of Pharmaceutical Research International · pp. 43–50 · Published 18 Feb 2022
10.9734/jpri/2022/v34i12A35554Abstract
Rivaroxaban (RN) is a recently developed potent oral anticoagulant. The aim of the present study envisages compatibility studies of rivaroxaban with crospovidone, sodium startch glycolate, magnesium stearate, talc, microcrystalline cellulose, aerosil, HPMC K100 M, croscarmellose sodium using Differential scanning calorimeter and FTIR spectrophotometer. DSC thermograms, of rivaroxaban and physical mixture of individual pharmaceutical excipient, exhibited the range of transition of the drug in between 224ºC and 232ºC. The FTIR graphs showed that the wave numbers of rivaroxaban, matched with all the chosen pharmaceutical excipients combinations. Thus the DSC and FTIR studies showed that RN was not interactive with selected pharmaceutical excipients and can be carried forward for further studies.
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