Relapse, Recurrence and Re-infection with SARS-Cov-2 after Recovery from COVID-19

Abstract

This review article throws light upon the frequency of patients that are coming out to be re-positive even after complete remission from the illness, and also what can be the possible causes for the same, and how to prevent such cases and management of such patients. This is important study because usually people once getting cured from the disease are in a mindset that they wont be infected again, so even the preventive measures are neglected by the population, so understanding this would make people more aware about the personal prevenyion and how to keep themselves safe during the pandemic. The whole world is in pain due to increase of number of cases and deaths due to novel corona virus (called COVID-19) which came upon in late 2019 in Wuhan city, in China. This viral entity causes a variety of symptoms that range from mild illness to moderate illness. Breathing difficulties and death occur in very severe cases. The most common earliest manifestation include fever, cough, cold, myalgia, chest pain, diarrhoea and headache. This disease is mainly spread through respiratory droplets which are brought about a person who is infected when he or she coughs, sneezes, or exhales. For SARS-CoV-2, the timing, size, and duration of humoral immunity are unknown. However, understanding this is critical in order to predict the pandemic's expected future dynamics, to guide methods for allowing social distancing measures to be relaxed, and to understand as to how to deploy the vaccine doses for achieving the maximum impact. So, since this disease is wrecking homes all over the world. There comes a necessity to be able to know about it at the earliest and effectively treating the patients by various drug modalities. Many studies are being done on the same. Tests for detecting coronavirus infection include RT-PCR, Rapid Antigen Testing, Antibodies testing, Chest Xray and some blood markers like CRP, D-dimer, LFT, KFT, Immunoglobulins etc. And with the upcoming testing options there also has been reports of reinfection or basically repeat RT-PCR test coming out to be positive after the recovery of the previous infection. According to many studies, it is found that RT-PCR coming out to be positive in patients that have recovered from the disease. This article aims to conduct a review that will summarize the epidemiological as well as clinical characteristics of these patients and also know about the possible explanations for these kind of recurrences, the contagiousness of re-positive SARS-CoV-2 virus, and the management ofCOVID-19 patients after they are discharged from the hospital.