Recent Studies on the Therapeutic and Prophylactic Effect of Some Agents on Experimental Induced Parkinson Disease Models Review
Asian Journal of Research in Biochemistry · pp. 1–18 · Published 23 Feb 2021
10.9734/ajrb/2021/v8i230175Abstract
Neurodegeneration include disease of the central nervous system (CNS) such as Parkinson’s disease (PD). The sign of this disease include destruction of dopaminergic neuronal cells. Main causes of this disease are unknown, but several studies reported polygenic causes. These include free radicals, malfunction of mitochondria, protein oxidation and DNA denaturation. Several reports implicated the involvement of oxygen species and stresses cause by over accumulation of reactive oxygen species in the contribution to the cascade that resulted in diminishing of dopamine cells destruction in this disease. Generally, natural defensive substances such as bio-cartelized (proteineous and non proteineous) from natural or synthetic sources played a unique role in protecting the susceptible neuronal cells from the adverse effects of the reactive oxygen species. In most cases antioxidant enzyme production by the body system diminished with advance age. Hence, treatment with antioxidant potential agent or administration of antioxidant substance with the common drugs used in the treatment of PD may yield positive result in protecting neurons from degenerative changes caused by reactive oxygen species. Recent studies on the therapeutic and prophylactic effect of some agents on experimental induced PD summarized in this review paper.
References (28)
- 1 Health benefits of resveratrol: Evidence from clinical studies [DOI]
- 2 Alzheimer’s Disease and Parkinson’s Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals [DOI]
- 3 Selegiline: a molecule with innovative potential [DOI]
- 4 Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala [DOI]
- 5 Flavonoids as a Natural Enhancer of Neuroplasticity—An Overview of the Mechanism of Neurorestorative Action [DOI]
- 6 Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals [DOI]
- 7 Astaxanthin Protects Retinal Photoreceptor Cells against High Glucose-Induced Oxidative Stress by Induction of Antioxidant Enzymes via the PI3K/Akt/Nrf2 Pathway [DOI]
- 8 Alpha lipoic acid antagonizes cytotoxicity of cobalt nanoparticles by inhibiting ferroptosis-like cell death [DOI]
- 9 Therapeutic Potential of Ursonic Acid: Comparison with Ursolic Acid [DOI]
- 10 Effect of Selenium Source and Level on Performance, Egg Quality, Egg Selenium Content, and Serum Biochemical Parameters in Laying Hens [DOI]
- 11 Recent Advances on the Neuroprotective Potential of Antioxidants in Experimental Models of Parkinson’s Disease [DOI]
- 12 Melatonin/polydopamine nanostructures for collective neuroprotection-based Parkinson's disease therapy [DOI]
- 13 Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design [DOI]
- 14 Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult [DOI]
- 15 Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson’s Disease [DOI]
- 16 MicroRNA‐182 exacerbates blood‐brain barrier (BBB) disruption by downregulating the mTOR/FOXO1 pathway in cerebral ischemia [DOI]
- 17 Protective effect of rutin isolated from Spermococe hispida against cobalt chloride-induced hypoxic injury in H9c2 cells by inhibiting oxidative stress and inducing apoptosis [DOI]
- 18 eNOS-Nitric Oxide System Contributes to a Novel Antiatherogenic Effect of Leonurine via Inflammation Inhibition and Plaque Stabilization [DOI]
- 19 Psychotic Disorders, Definition, Sign and Symptoms, Antipsychotic Drugs, Mechanism of Action, Pharmacokinetics & Pharmacodynamics with Side Effects & Adverse Drug Reactions: Updated Systematic Review Article [DOI]
- 20 Curcumin protects against rotenone-induced neurotoxicity in cell and drosophila models of Parkinson’s disease [DOI]
- 21 Neuropeptide VGF-Derived Peptide LQEQ-19 has Neuroprotective Effects in an In Vitro Model of Amyotrophic Lateral Sclerosis [DOI]
- 22 Iranian brown propolis possesses neuroprotective effect against ischemic neuronal damage in mice [DOI]
- 23 Cytoprotective effect of methanolic extract of Nardostachys jatamansi against hydrogen peroxide induced oxidative damage in C6 glioma cells. [DOI]
- 24 Primary Amine Modified Gold Nanodots Regulate Macrophage Function and Antioxidant Response: Potential Therapeutics Targeting of Nrf2 [DOI]
- 25 Styrene Oxide Caused Cell Cycle Arrest and Abolished Myogenic Differentiation of C2C12 Myoblasts [DOI]
- 26 Neuroprotective Effects of 3α-Acetoxyeudesma-1,4(15),11(13)-trien-12,6α-olide Against Dopamine-Induced Apoptosis in the Human Neuroblastoma SH-SY5Y Cell Line [DOI]
- 27 ROLE OF NATURAL SUBSTANCES AND VITAMIN SUPPLEMENTATION IN TINNITUS PREVENTION AND TREATMENT [DOI]
- 28 QuitPuff: A simple method using lipid peroxidative changes in saliva to assess the risk of oral precancerous lesions and oral squamous cell carcinoma in chronic smokers [DOI]
Cited by 2
Olusegun G. Adebayo, Wadioni Aduema, Modo U. Emmanuel · Neurochemical Research · 2022
Showing 1 of 2 known citations — external sources report more than can currently be individually listed.
Related research
- Salivary Lipid Peroxidation and Antioxidant Status in Nigerian Cigarette Smokers with or Without Periodontitis — shares topic coverage
- Profile of Biochemical and Oxidative Stress Markers in Male Athletes Following Strenuous Exercise Session — shares topic coverage
- Atherogenicity, Oxidative Stress, Heavy Metals and Bioelements Status in Hypertensive Nigerians in an Urban Population — shares topic coverage
- Oxidative Stress Biomarkers (Malondialdehyde, Superoxide Dismutase, and Catalase) as Predictors of Cardiovascular Disease Risk: A Review — shares topic coverage
- Ebselen a Seleno-organic Molecule Inhibits Alteration in the Biological Responses in Hypoxic Human Alveolar Lung Epithelial Cells — shares topic coverage
Article metrics
Real usage data collected on this platform.
59
Page views
0
PDF downloads
30
Outbound clicks
2
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.