Recent Advances in Chalcones: Synthesis, Transformation and Pharmacological Activities
Oluwaseyi Bukky Ovonramwen, Bodunde Joseph Owolabi, Amowie Philip Oviawe
Asian Journal of Chemical Sciences · pp. 1–16 · Published 21 Sep 2019
10.9734/ajocs/2019/v6i318996Abstract
Chalcones are useful intermediates in the synthesis of heterocyclic compound and the unique reagents in organic synthesis. The usual approach to obtain chalcones is through Claisen-Schmidt condensation. Several novel heterocyclic chalcone analogs have emerged. Chalcones are multifunctional molecules that possess promising pharmacological activities. Chalcones are known for anti-cancer, antioxidant, anti-inflammatory, anti-microbial, anti-tubercular, antileishmanial, antimalarial, anthelmintic, osteogenic activities. This review article focuses on recent applications of Claisen-Schmidt condensation reaction employed in the synthesis of chalcone, its transformation to heterocyclic compounds and pharmacological activities.
References (21)
- 1 I 2 -Mediated Oxidative C–N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones and Hydrazines [DOI]
- 2 The Complete Mechanism of an Aldol Condensation [DOI]
- 3 Base-Promoted Synthesis of N-Substituted 1,2,3-Triazoles via Enaminone–Azide Cycloaddition Involving Regitz Diazo Transfer [DOI]
- 4 A Facile FeCl3/I2-Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones [DOI]
- 5 Metal-Free Assembly of Polysubstituted Pyridines from Oximes and Acroleins [DOI]
- 6 Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance [DOI]
- 7 Synthesis of Functionalized Pyridines via Cu(II)-Catalyzed One-Pot Cascade Reactions of Inactivated Saturated Ketones with Electron-Deficient Enamines [DOI]
- 8 Synthesis and biological evaluation of chalcones as potential antileishmanial agents [DOI]
- 9 Regioselective Iodine-Catalyzed Construction of Polysubstituted Pyrroles from Allenes and Enamines [DOI]
- 10 Catalyst-free synthesis of 4-acyl- NH -1,2,3-triazoles by water-mediated cycloaddition reactions of enaminones and tosyl azide [DOI]
- 11 Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones—In Vitro and In Silico Study [DOI]
- 12 One-Pot Synthesis of Pyrrole-2-carboxylates and -carboxamides via an Electrocyclization/Oxidation Sequence [DOI]
- 13 Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media [DOI]
- 14 Synthesis of leading chalcones with high antiparasitic, against Hymenolepis nana, and antioxidant activities [DOI]
- 15 One-Pot Synthesis of Indole-3-acetic Acid Derivatives through the Cascade Tsuji–Trost Reaction and Heck Coupling [DOI]
- 16 Halo-Substituted Chalcones and Azachalcones Inhibited Lipopolysaccharited-Stimulated Pro-Inflammatory Responses through the TLR4-Mediated Pathway [DOI]
- 17 Synthesis of Polysubstituted 2-Aminoimidazoles via Alkene-Diamination of Guanidine with Conjugated α-Bromoalkenones [DOI]
- 18 Application of Chalcone in Synthesis of New Heterocycles Containing 1,5-Benzodiazepine Derivatives
- 19 Design and synthesis of 2-pyrazoline derivatives
- 20 Synthesis of Benzimidazole Derived Chalcones and their Heterocyclic Derivatives
- 21 An efficient synthesis of some new chalcone, acetyl pyrazoline and amino pyrimidine bearing 1,3,5- triazine nucleus as potential antimicrobial and antitubercular agent [DOI]
Cited by 0
No indexed citations yet.
Related research
- Newly Developed Epoxy-Polyol and Epoxy-Polyurethane From Renewable Resources — shares topic coverage
- (1H-Pyrrolo [2,3-b]pyridine)7-Azaindole Derivatives and Their Antiurease, Phosphodiesterase and β-glucuronidase Activity — shares topic coverage
- Synthesis and Theoretical Evaluation of New Binuclear Cr(III), Co(II) and Fe(III) Metal Complexes of Tetradentate Schiff Base and Its Biological Activity — shares topic coverage
- (1H-Pyrrolo [2,3-B] Pyridine) 7-Azaindole as Cholinesterase/ Glycation Inhibitors — shares topic coverage
- The Effect of Different Acid Chloride on Physical and Chemical Characterizations of Aryledinecycloalkanone Unsaturated Copolyesters — shares topic coverage
Article metrics
Real usage data collected on this platform.
30
Page views
0
PDF downloads
4
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.