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Research Article Open access CC BY 4.0

Reasons for Hyperhidrosis, Its Effects, and Novel Therapies

Aishwarya ABBURU, Azad RAYAPANENI, Praveen RAVULA, Rahul Nadigotla

Journal of Advances in Biology & Biotechnology · pp. 1018–1027 · Published 13 Jun 2025

10.9734/jabb/2025/v28i62460

Abstract

Excessive sweating is a symptom of a long-term medical condition called hyperhidrosis. Despite affecting 2-3% of the global population Millions of people around the world, it is not considered a public health concern. Because of social taboos, patient discomfort, and a general lack of awareness among the medical community, hyperhidrosis is commonly misdiagnosed and undertreated despite its seriousness. The illness has a significant impact on not only physical but also psychological and social well-being, causing disturbances in everyday routines, occupational performance, and interpersonal relationships (Kisielnicka et al., 2022). This report provides an integrated overview of findings from significant investigations, including the underlying pathophysiology, epidemiology, diagnostic approaches, and long-term consequences on quality of life. In certain anatomical areas, it also covers real-world applications and therapeutic experiences, especially with botulinum toxin, iontophoresis, and oral oxybutynin (Lowe et al., 2023).

Hyperhidrosis eccrine sweat glands aluminum chloride Iontophoresis microwave thermolysis ETS- Endoscopic Thoracic Sympathectomy sofpironim bromide

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