Microalbuminuria and Its Clinical Correlates in Individuals with Sickle Cell Trait: A Comparative Study
Ayoola Odeyemi, Adeola O. Ajibare, Olalekan E. Ojo, Boma Paul-Odo, Fatiu A. Arogundade
Asian Journal of Research in Nephrology · pp. 29–39 · Published 4 Apr 2022
Abstract
Background: Sickle Cell Disease (SCD) is a relatively common genetic disorder in Nigeria with attendant kidney disease. There is growing evidence that Sickle cell trait (SCT) may have smothering kidney disease. Microalbuminuria is a sensitive predictor of kidney damage. Aims: To determine the prevalence of microalbuminuria and its clinical correlates in individuals with SCT. Methodology: A hospital based cross-sectional study of 200 age and sex matched SCD patients divided equally into 2 groups of sickle cell anemia (SCA) and SCT with 100 controls with HbAA. All participants had blood hematology, chemistry and urine albumin/creatinine ratio (UACR) done. The study was done in Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State and Federal Medical Centre, Owo, Ondo State, between May 2016 to April 2017 Results: The SCA group comprised of 86 HbSS and 14 HbSC, SCT group had 96 HbAS and 4 HbAC while the control were all HbAA. The prevalence of microalbuminuria was 61%, 12% and 8% (p<0.0001) respectively across the group. Serum alanine aminotransferase and aspartate aminotransferase were the clinical parameters associated with the presence of microalbuminuria but was insignificant on regression analysis. Conclusion: Microalbuminuria is more prevalent in the SCD and SCT population and thus there may be a need to adopt measures of early detection and institute aggressive lifestyle modification to prevent chronic kidney disease.
Cited by 0
No indexed citations yet.
Related research
- A Review on Antibiotic Resistance in Chronic Kidney Disease (CKD) Patients Undergoing Dialysis — shares topic coverage
- Lack of Awareness among Renal Transplant Recipients Regarding Consumption of Phosphate-containing Processed Food and Drinks — shares topic coverage
- Haematologic Profile of Patients with Chronic Kidney Disease in Port Harcourt, South-South Nigeria — shares topic coverage
- Prevalence of Renal Dysfunction and Its Relationship to CD4 and TNF Alpha of HIV Positive Individuals on Anti-retroviral Therapy in Port Harcourt — shares topic coverage
- Prevalence of Iron Deficiency Anemia among Chronic Kidney Disease Patients in Kaveri Delta Region, Tamilnadu, India — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.