Rare Double Heterozygous of HbD/HbG in a Nigerian: A Case Report
Olusogo Ebenezer Busari, Taiwo Rachael Kotila, Omotola Toyin Ojo
International Journal of Research and Reports in Hematology · pp. 10–15 · Published 17 May 2018
Abstract
Aim: To advocate the use of newer and improved methods towards accurate diagnosis of haemoglobinopathies Case Presentation: A rare case of double heterozygous of HbD/G in a pregnant female Nigerian who had present to the antenatal clinic for routine Haemoglobin electrophoresis. She had previously been diagnosed as HbAS using capillary electrophoresis and HPLC techniques. Discussion: Capillary zone electrophoretograms showed the presence of peaks in zone Hb A, Hb D, C and a small peak in Z1 zone. Bio-Rad D10 chromatogram also indicated the presence of four peaks which are identified as Hb A, Hb D, Hb G, and hybrid of HbD/HbG. A peak in Hb D zone of capillary electrophoresis was due to co-migration of Hb D and Hb G variants. The small peak in Z1 zone indicated the presence of alpha chain variant of HbG. Conclusion: The case exemplifies the need to use more advanced methods, including DNA analysis in order to accurately diagnose haemoglobinopathies in the nation with the largest burden of sickle cell disease.
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