Method Development for Chiral Purification of Racemic Clopidogrel Using Chiral Stationary Phase
Sangeeta Sangwan, Sharwan K. Dewan, Rajesh K. Thaper
International Research Journal of Pure and Applied Chemistry · pp. 19–30 · Published 19 Dec 2014
10.9734/IRJPAC/2015/14075Abstract
HPLC method was developed for resolution of racemic clopidogrel into its chirally pure enantiomer of interest. Screening experiments were performed using amycoat and cellucoat analytical chiral stationary phases in organic solvent based polar and nonpolar eluents in various combinations. Based on the screening outcomes, the compound loading studies were carried out using amycoat higher µ particle sized chiral stationary column by keeping in mind the scale up studies to avoid high back pressure that can limit the efficiency of separation.
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