Quercetin Supplementation Reduces Maternal Hyperglycemia in a Type 2 Diabetes Mellitus Mouse Model
J. Claudio Gutierrez, M. Renee Prater, Steven D. Holladay
Annual Research & Review in Biology · pp. 306–311 · Published 5 Oct 2013
10.9734/ARRB/2014/5431Abstract
Aims: Pregnancy may be complicated by diabetes mellitus. The use of natural antioxidants may alleviate the increased glucose levels in the diabetic pregnancy. Methodology: The combination of high Fat Diet (HFD) and streptozocin (STZ) was used pre-breeding in CD1 female mice to generate maternal hyperglycemia. A subgroup of the females received quercentin (Q) supplementation in their HFD. Results: Hyperglycemic females supplemented with Q displayed significantly decreased blood glucose levels at gestation days 10 and 17. Conclusion: These results suggest quercetin could have utility as a supplement for diabetic women during pregnancy, and could represent a protection for the offspring of diabetic mothers.
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