J. Claudio Gutierrez

Quercetin Supplementation Reduces Maternal Hyperglycemia in a Type 2 Diabetes Mellitus Mouse Model

J. Claudio Gutierrez, M. Renee Prater & Steven D. Holladay · Annual Research & Review in Biology · 2013

Aims: Pregnancy may be complicated by diabetes mellitus. The use of natural antioxidants may alleviate the increased glucose levels in the diabetic pregnancy. Methodology: The combination of high Fat Diet (HFD) and streptozocin (STZ) was used pre-breeding in CD1 female mice to ge...

Open access Research Article 10.9734/ARRB/2014/5431

Fetal Myocardial Reduction in Hyperglycemic Mouse Pregnancy is Associated with Dys-regulated Expression of the Anti-apoptotic Gene Bcl-2 in the Developing Heart. Preliminary Results

J. Claudio Gutierrez, M. Renee Prater, Patricia Navarrete & Steven D. Holladay · Annual Research & Review in Biology · 2013

Aims: We previously detected significant late-gestation ventricular myocardial reduction in fetal mouse hearts from hyperglycemic dams. Flow cytometric analysis of the myocardial cells showed an enhanced rate of apoptosis, suggesting dysregulated cell death as a mechanism associa...

Open access Research Article 10.9734/ARRB/2014/5085