Prophylactic Potential of Corchorus olitorius Leaves against Experimentally-induced Dyslipidaemia

Abstract

Background: Our literature searches revealed that no study has examined the ameliorative impact of Corchorus olitorius leaves on dyslipidaemia caused by potassium bromate (KBrO3). Therefore, the purpose of this study was to determine whether C. olitorius leaves could prevent KBrO3-induced dyslipidaemia. Methodology: Fresh Corchorus olitorius (jute) plants were gathered from the Institute of Agricultural Research and Training, Moor Plantation, Nigeria. Using a soxhlet system and 95% ethanol as the solvent, they were extracted. For the experiment, 24 male Wistar rats were used. They were allowed to be used to a lab environment for seven (7) days before the experiment. They were divided into groups A, B, C, and D at random. Group A received oral distilled water as the control group. In addition to the 100 mg/kg body weight of potassium bromate given to groups B, C, and D, animals in groups C and D also received 100 and 200 mg/kg body weight of C. olitorius, respectively. Oral gavage was used to administer C. olitorius extract and freshly made potassium bromate to rats every day for 28 days. Twenty-four hours after the last treatment, the animals were killed under gentle sedation with diethyl ether. Blood was drawn by puncturing the heart. Also taken from the animals was their heart. Results: In comparison to the untreated group, the research animals given KBrO3 had considerably higher plasma levels of total cholesterol, triglycerides, LDL, VLDL, and the CHD risk ratio, whereas their levels of HDL and the HDL/LDL ratio were much lower. When compared to the control group, treatment with KBrO3 significantly decreased cardiac levels of total cholesterol, HDL, and HDL/LDL ratio, while increasing levels of triglycerides, LDL, and VLDL as well as the CHD risk ratio. C. olitorius reduced these abnormalities in a dose-dependent manner. Conclusion: Corchorus olitorius leaves were found to have hypolipidaemic effect against Potassium bromate-induced dyslipidaemia, increase HDL and reduce cardiovascular disease ratio.