Hepatoprotective and Anti-hyperlipidemic Effects of Ethanolic Extract of Terminalia arjuna in a High-fat-induced Hyperlipidemic Rat Model

Abstract

Herbalism is the use of herbs and herbal medicines to improve and preserve health, ward off illness, or cure existing conditions. It is possible to hear the terms "herbal remedy" and "herbal medicine" used interchangeably. This study examined the effects of an extract from Terminalia arjuna on the lipid profiles of rats suffering from hyperlipidemia due to a high-fat diet. In terms of liver function, the SGPT and SGOT levels were statistically significant (p<0.05) in groups 5 and 6, when the doses were 600 mg/kg and 900 mg/kg, respectively. Groups 4, 5, and 6 showed significantly higher levels of creatinine (p<0.05) during the renal function test. A mixed high-fat diet was administered to the groups at dosages of 300, 600, and 900 mg/kg, respectively. However, there were no statistically significant outcomes from the urea investigation. The levels of HDL were shown to be significantly affected (p<0.05) by the dosages of high fat and extract given to groups 5 and 6, respectively, when it came to HDL and LDL. The examination of total cholesterol and triglycerides yielded no statistically significant results. The main goal of this study is to find out what happens to the lipid profile of hyperlipidemic albino rats when they are given an ethanolic T. arjuna extract. In rat models, the present investigation demonstrated that T. arjuna exerted a hyperlipidemic effect by substantially raising cholesterol levels. The plant's ability to protect the heart is due to its bioactive components, which include tannins, flavonoids, and phenolics. We need to do further processing on the ethanolic extract of T. arjuna to understand how certain biologically active principles function.