An Inter Mammalian Microbiome-Immune-Axis MIA

Abstract

There is a mutual bidirectional cross-talk between mammalian microbiomes MM and their respective immune systems during the host homeostatic and disease states, the microbiome- immune axis. The objective of the present opinion paper was to map the current status of the microbiome-immune axis updates. Human gut microbiome diversity decreases rapidly after autologous stem cell transfer. Myelopoiesis in human is regulated by signals from microbiome reaching the bone marrow. Some animal heat treated gut bacterial antigens induces proinflammatory cytokines in rabbits ileal and villus cultures while other animal heat treated gut bacterial antigens initiated anti-inflammatory cytokines using same test culture systems. Rabbits gut microbiome modulates brain development and function with coordinative helping role of the immune system. Rabbit models for rhino-sinusitis and cystic fibrosis were found associated with microbiome dysbioses in nose and gut microbiomes respectively and simulating that of man. When the development of mice microbiome became arrested the immune system undergoes stunting growth and development. Obese mice have shown dysbiotic microbiome. Thus, the paradigm of microbiome-immune axis MIA have shown that the potentials of the monkeys, rabbit and mice microbiomes can be translated to human welfare providing some limitations.