Therapeutic Effect of Hydatid Cyst Liquid on Melanoma Tumor Growth in Mouse Model
Hossein Yousofi Darani, Seyedeh Maryam Sharafi, Fariborz Mokarian, Morteza Yousefi, Sayedeh Ala Sharafi, Rasool Jafari
Journal of Advances in Medicine and Medical Research · pp. 1–7 · Published 3 Oct 2016
10.9734/BJMMR/2016/27220Abstract
Introduction: Hydatid cyst is the larval stage of Echinococcus granulosus which develops in various human and livestock animals tissues. This hydatid cyst composed of several layers. Previous investigations have shown that the prevalence of hydatid cyst in cancer patients is significantly lower than in healthy individuals. In animal models preventive effect of the hydatid cyst antigens in reduction of tumor growth has been shown. Due to the effect of live protosculex and hydatid cyst antigens on reducing the growth of cancer cells in culture medium, in this study therapeutic effect of hydatid cyst liquid on the growth of melanoma tumor in mice (C57 black) has been investigated. Methods: In this Experimental study, the population studies were C57 black mice. Six groups of mice were injected with 106 melanoma cells in their chest site subcutaneously. Then the mice were injected with hydatid cyst fluid either with or without albendazole. From the second week, the tumor size was measured using a calipers and tumor area was calculated and the mean tumor area compared with those of control groups using One-way ANOVA test. Results: The mean tumor area, in groups which injected with hydatid cyst fluid (case groups), was less than the mean tumor area in the control groups and this difference was statistically significant. Conclusion: This study showed that hydatid cyst fluid may have therapeutic effect on melanoma cancer growth.
Cited by 11
Maha M. Eissa, Maha R. Gaafar, Layla K. Younis · Infectious Agents and Cancer · 2023
Wang Guan, Xiaoqin Zhang, Xiao Wang · Frontiers in Pharmacology · 2019
Nahla El Skhawy, Maha M. Eissa · Experimental Parasitology · 2023
Manfred Schreiber, Vojtěch Vajs, Petr Horák · PeerJ · 2024
Shiwanthi L. Ranasinghe, Donald P. McManus · Frontiers in Medicine · 2018
Nima Ameli, Alireza Masoumi, Mahnaz Kerachi · World's Veterinary Journal · 2023
Hongyu Li, Chaojun Shan, Yunhuan Zhu · Frontiers in Immunology · 2025
Soheil Sadr, Hassan Borji · Current Cancer Therapy Reviews · 2023
Hossein Yousofi Darani, Seyedeh Maryam Sharafi · International Journal of Environmental Health Engineering · 2022
Neha Sylvia Walter, Shalmoli Bhattacharyya · Medical Oncology · 2024
Related research
- Anal Melanoma: An Atypical Case — shares topic coverage
- All-Trans Retinoic Acid Downregulates Epidermal Growth Factor Receptor Mediated Regulation of Matrix Metalloproteinase-2 in B16F10 Murine Melanoma Cells — shares topic coverage
- Diagnosis of Melanoma Based on the Sparse Auto-Encoder for Feature Extraction — shares topic coverage
- Panophthalmitis Masquerading as Ocular Melanoma-an Eye Opener — shares topic coverage
- Retinopathy Associated with Adjuvant Interferon in a Patient with Malignant Melanoma: A Case Report and Review of the Literature — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
11
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.