Protective Effects of Flavonoids-rich and Saponins-rich Extracts from Tiger Nuts and Date Fruits on Prostate Histoarchitechture in Aluminum-exposed Wistar Rats
Agaba, Eric Agim, Ujah, Williams Oche, Enang, Kingsley Bassey, Fischer, Victor A, Emmanuel I. Odom, Adie, Christopher Utsu
Journal of Complementary and Alternative Medical Research · pp. 1–11 · Published 3 Jan 2025
10.9734/jocamr/2025/v26i1610Abstract
Aim: To evaluate the histological effects of flavonoid and saponin fractions from Cyperus esculentus (tiger nuts) and Phoenix dactylifera (date fruits) on the prostate gland of Wistar rats exposed to aluminum chloride, focusing on their potential protective properties against aluminum-induced toxicity. Study Design: A randomized experimental study involving twenty-five male Wistar rats divided into five groups. Groups were treated with normal saline (control), aluminum chloride, and different combinations of flavonoid and saponin extracts for 28 days. Place and Duration: Conducted at the animal breeding facility of the College of Medical Sciences, University of Calabar, over a month. Methods: Male Wistar rats were acclimatized for seven days, then assigned to five treatment groups. Flavonoids and saponins were extracted from Cyperus esculentus and Phoenix dactylifera. The groups received oral administration of extracts and aluminum chloride once daily for 28 days. Prostate tissues were collected post-treatment and processed with hematoxylin and eosin (H&E) for histological evaluation. Results: Histological analysis showed that the control group had healthy prostate architecture, while the aluminum chloride-treated group presented significant dysplastic changes typical of benign prostatic hyperplasia (BPH). Treatment with flavonoid and saponin fractions resulted in moderate histological improvements. The combination of both extracts exhibited enhanced protective effects, stabilizing prostate architecture and preventing severe stromal hyperplasia. Conclusion: Flavonoid and saponin fractions from Cyperus esculentus and Phoenix dactylifera demonstrate protective effects against aluminum chloride-induced histopathological changes in the prostate of Wistar rats, suggesting potential dietary interventions to mitigate environmental toxin impacts on prostate health. Further investigation into their mechanisms and broader applications is warranted.
References (21)
- 1 Aluminium toxicosis: a review of toxic actions and effects [DOI]
- 2 The neurotoxicity of environmental aluminum is still an issue [DOI]
- 3 Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine [DOI]
- 4 Tiger Nut (Cyperus esculentus L.): Nutrition, Processing, Function and Applications [DOI]
- 5 The binding, transport and fate of aluminium in biological cells [DOI]
- 6 Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets [DOI]
- 7 Biological, Nutritive, Functional and Healthy Potential of Date Palm Fruit (Phoenix dactylifera L.): Current Research and Future Prospects [DOI]
- 8 Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus [DOI]
- 9 Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System [DOI]
- 10 Aluminum chloride caused liver dysfunction and mitochondrial energy metabolism disorder in rat [DOI]
- 11 Medical Treatment of Benign Prostatic Hyperplasia
- 12 Protective effects of ginseng stem-leaf saponins on D-galactose-induced reproductive injury in male mice [DOI]
- 13 A New Proposed Rodent Model of Chemically Induced Prostate Carcinogenesis: Distinct Time-Course Prostate Cancer Progression in the Dorsolateral and Ventral Lobes [DOI]
- 14 TIGER NUT (CYPERUS ESCULENTUS): SOURCE OF NATURAL ANTICANCER DRUG? BRIEF REVIEW OF EXISTING LITERATURE [DOI]
- 15 Novel Insights into the Role of the Antioxidants in Prostate Pathology [DOI]
- 16 Basal cell proliferation in benign prostatic hyperplasia [DOI]
- 17 Leveraging metabolomics and ionomics to illuminate aluminum-induced toxicity in mouse organs [DOI]
- 18 Revolutionizing of bioactive natural products in prostate cancer research and care: Promising discoveries and future directions [DOI]
- 19 Neuroprotective Effects of Heinsia crinita and Coconut Water in a Scopolamine-Induced Alzheimer's Model in Albino Rats: Biochemical Changes, Cellular Health, and Neuronal Activity [DOI]
- 20 Histomorphological Assessment of Adrenal Glands in Wistar Rats Following Myricetin Treatment Against MNU-Induced Oxidative Stress [DOI]
- 21 Benign Prostatic Hyperplasia [DOI]
Cited by 1
ODEY PAUL ANYIOM, Abue Andrew Donatus, Raymond Ugochukwu Okolo · Asian Journal of Pharmaceutical and Clinical Research · 2026
Related research
- Effect of Pearl Millet on Glycaemic Control and Lipid Profile in Streptozocin Induced Diabetic Wistar Rat Model — shares topic coverage
- Effect of Beet Root (Beta vulgaris), White and Red Radish (Raphanus sativus and Raphanus longipinnatus) Juice Extract, on Salt Induced Hypertensive Wistar Rats — shares topic coverage
- Effect of Palm Kernel Oil on Plasma Sodium, Potassium and Chloride in Wistar Rats Induced with Febrile Seizures — shares topic coverage
- Effects of Nigella sativa Linn. Oil on Gut Bacteria and Liver Function Status of Albino Wistar Rats — shares topic coverage
- Effect of Garcinia Kola Consumption on Lipid Profile and Body Weight of Rats Fed with High Fat Diet — shares topic coverage
Article metrics
Real usage data collected on this platform.
76
Page views
0
PDF downloads
38
Outbound clicks
1
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.