Skip to content
Research Article Open access CC BY 4.0

Effect of Beet Root (Beta vulgaris), White and Red Radish (Raphanus sativus and Raphanus longipinnatus) Juice Extract, on Salt Induced Hypertensive Wistar Rats

Essien E. F., Anyika-Elekeh J. U.

Asian Journal of Medicine and Health · pp. 39–56 · Published 27 Jan 2024

10.9734/ajmah/2024/v22i1974

Abstract

Background: Hypertension is one of the major global health challenges with high prevalence and undesirable complications, and is a major cause of premature death worldwide. Objective: This study was conducted to evaluate the effect of juice extracted from beetroot (BR), red radish (RR) and white radish (WR) tubers on experimentally induced hypertension in 10-week-old Wistar rats. Methodology: Total of 35 rats was randomly divided into seven (7) experimental groups A - G with 5 rats each. Rats in group A were not induced (normotensive group). All the rats in groups B-G were induced with hypertensive agent. Group B was not treated (negative control), groups C-G were treated simultaneously with a dose of 800 mg/kg body weight (orally) of BR, RR, WR, BR+RR combination, and standard drug (5mg Amlodipine) respectively. The study lasted for a period of 28 days during which the blood pressure and heart rate (HR) of each of the experimental rats were measured at 0, 7, 14, 21 and 28th day using Stethoscope technique. The interpretation of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were made from pulse tracings using Aneroid Sphygmomanometer. The mean blood pressure (MBP) was calculated from SBP and DBP. Results: The BR, RR, WR and combination of BR+RR, did decrease the number of heart beats/minute from 192.00/minute to 208.80/minute which is within the normal base line, whereas the untreated rats recorded increase from 192.00/minute to 246.80/minute. The result showed that the hypertensive rats recorded higher (P<0.05) mean values of SBP, the treated groups altered the rise from 110.40 mmHg to 100.40mmHg with the standard drugs, followed by the white radish treatment group, the combination of BR+RR, before RR, lastly the BR group. For DBP, at week 4, same impact reflected again, but week 2 and week 3 had WR to have the best effect, followed by BR +RR, then RR before the standard drug and then Beetroot.  The BR + RR juice performed better than the individual RR and BR juice groups, suggesting possible synergistic effect. Conclusion: The 3 juice extracts had demonstrated varying degrees of protection, provided scientific evidence of their anti- hypertensive activities in an experimentally induced hypertension. Further studies are hereby recommended to isolate the specific biomolecule active agent(s) and investigate the mechanism of action.

Blood pressure beet root white radish red radish juice extract hypertensive wistar rats

References (22)

  1. 1 Global status report on noncommunicable diseases 2010.
  2. 2 Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants [DOI]
  3. 3 Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite [DOI]
  4. 4 Bioactive compounds of beetroot and utilization in food processing industry: A critical review [DOI]
  5. 5 Impact of processing of red beet on betalain content and antioxidant activity [DOI]
  6. 6 Inorganic Nitrate and Beetroot Juice Supplementation Reduces Blood Pressure in Adults: A Systematic Review and Meta-Analysis [DOI]
  7. 7 Hypertension awareness, treatment and control in Africa: a systematic review [DOI]
  8. 8 Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes [DOI]
  9. 9 Nutritional and phytochemical characterization of radish (Raphanus sativus): A systematic review [DOI]
  10. 10 The Nitrate-Independent Blood Pressure–Lowering Effect of Beetroot Juice: A Systematic Review and Meta-Analysis [DOI]
  11. 11 Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects [DOI]
  12. 12 Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review [DOI]
  13. 13 Studies on evaluation of physical and chemical composition of beetroot (Beta vulgaris L.)
  14. 14 Reactive oxygen species in tissue injury.
  15. 15 Nutritional assessment of beetroot (Beta vulgaris L.) powder cookies [DOI]
  16. 16 Dietary contributors to hypertension in adults reviewed [DOI]
  17. 17 Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G1 cell cycle arrest [DOI]
  18. 18 Antioxidative effects of daikon sprout (Raphanus sativus L.) and ginger (Zingiber officinale Roscoe) in rats [DOI]
  19. 19 Prevalence of hypertension and diabetes and their determinants among commercial drivers in Ibadan metropolis, South-Western Nigeria [DOI]
  20. 20 Bioactive glucosinolates and antioxidant properties of broccoli seeds cultivated in Thailand
  21. 21 Different Structural Alterations in Individual Conduit Arteries of SHRs Compared to Wistar Rats From the Prehypertensive Period to Late Adulthood [DOI]
  22. 22 Determination of the Total Alkaloids in Semen Raphani by Acid Dye Colorimetry

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

67

Page views

0

PDF downloads

18

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.