Prospects of Sea Anemone Peptides for Pharmacology
Margarita Monastyrnaya, Emma Kozlovskaya
International Journal of Biochemistry Research & Review · pp. 52–59 · Published 26 Jun 2024
10.9734/ijbcrr/2024/v33i6888Abstract
It has been found that the genes of a number of protein components of sea anemone venoms underwent significant diversification in the course of evolution. The elucidation of the molecular mechanisms of sea anemone peptides interactions with targets let investigators in the last decade actively study the molecular organization and the functioning mechanisms of cytoplasmic membranes, the various types and subtypes of ion channels/receptors involved in the processes of perception, processing, intra- and intercellular signal transduction, both in a body physiological and pathological state. A short characteristic of the structure and functional activity of several classes of sea anemone peptide components, which have pronounced pharmacological potential, is presented in this mini-review.
References (29)
- 1 A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid‐sensitive channel in sensory neurons [DOI]
- 2 Peptide therapeutics from venom: Current status and potential [DOI]
- 3 Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases [DOI]
- 4 Kalicludines and Kaliseptine [DOI]
- 5 Analgesic Compound from Sea Anemone Heteractis crispa Is the First Polypeptide Inhibitor of Vanilloid Receptor 1 (TRPV1) [DOI]
- 6 Sea Anemones: Quiet Achievers in the Field of Peptide Toxins [DOI]
- 7 Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery [DOI]
- 8 Nicotinic Acetylcholine Receptors Are Novel Targets of APETx-like Toxins from the Sea Anemone Heteractis magnifica [DOI]
- 9 Potassium Channel Blockade by the Sea Anemone Toxin ShK for the Treatment of Multiple Sclerosis and Other Autoimmune Diseases [DOI]
- 10 The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus) [DOI]
- 11 Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor [DOI]
- 12 Sea anemone cytolysins as toxic components of immunotoxins [DOI]
- 13 Actinoporins from the sea anemones, tropical Radianthus macrodactylus and northern Oulactis orientalis: Comparative analysis of structure–function relationships [DOI]
- 14 Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease [DOI]
- 15 A new multigene superfamily of Kunitz-type protease inhibitors from sea anemone Heteractis crispa [DOI]
- 16 New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels [DOI]
- 17 Kunitz-Type Peptides from the Sea Anemone Heteractis crispa Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities [DOI]
- 18 APETx-Like Peptides from the Sea Anemone Heteractis crispa, Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels [DOI]
- 19 Sea Anemone Heteractis crispa Actinoporin Demonstrates In Vitro Anticancer Activities and Prevents HT-29 Colorectal Cancer Cell Migration [DOI]
- 20 The Sea Anemone Neurotoxins Modulating Sodium Channels: An Insight at Structure and Functional Activity after Four Decades of Investigation [DOI]
- 21 Anxiolytic, Analgesic and Anti-Inflammatory Effects of Peptides Hmg 1b-2 and Hmg 1b-4 from the Sea Anemone Heteractis magnifica [DOI]
- 22 New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa [DOI]
- 23 Peptide fingerprinting of the sea anemone Heteractis magnifica mucus revealed neurotoxins, Kunitz-type proteinase inhibitors and a new β-defensin α-amylase inhibitor [DOI]
- 24 Multigene Family of Pore-Forming Toxins from Sea Anemone Heteractis crispa [DOI]
- 25 Atypical Reactive Center Kunitz-Type Inhibitor from the Sea Anemone Heteractis crispa [DOI]
- 26 Magnificamide, a β-Defensin-Like Peptide from the Mucus of the Sea Anemone Heteractis magnifica, Is a Strong Inhibitor of Mammalian α-Amylases [DOI]
- 27 Role of Adrenomedullin in Trophoblast Invasion [DOI]
- 28 Antimicrobial Proteins: Key Components of Innate Immunity [DOI]
- 29 MASS SPECTROMETRY | Peptides and Proteins [DOI]
Cited by 0
No indexed citations yet.
Article metrics
Real usage data collected on this platform.
13
Page views
0
PDF downloads
13
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.