Skip to content
Research Article Open access CC BY 4.0

Predictors of the Occurrence of Tuberculosis in HIV-infected Adults during the First Six Months of Antiretroviral Therapy in Kisangani, DR Congo

Dieudonné Lobela Bumba, Issa Yakusu Issa, Daniel Kazadi Musakayi, Floribert Olinda Loku, Jacques Ossinga Bassandja, Dieu-Merci Mbumba Lupaka, Mbo Mukonkole Jean Paulin, Atoba Bokele Camille-Rémy, Charles Kayembe Tshilumba

Asian Journal of Research in Infectious Diseases · pp. 28–33 · Published 21 Mar 2020

10.9734/ajrid/2020/v3i330129

Abstract

Objective: To determine the predictive factors for the occurrence of tuberculosis (TB) in adults infected with the human immunodeficiency virus (HIV) during the first 6 months of antiretroviral therapy (ART) in Kisangani. Methods: A case-control study was carried out during the period from January 1, 2017 to December 31, 2018. Clinical data were collected retrospectively from patients receiving antiretroviral therapy in the city of Kisangani. Of a total of 1,161 HIV-infected patients included in this study, 58 of them developed TB. The diagnosis of tuberculosis was made on the presence of Acid-Alcohol-Resistant Bacile (BAAR) on at least one biological sample or on the basis of a bundle of clinical and paraclinical arguments. This test is done during the first six months of initiating anti retroviral therapy (ART). Predictive factors for the onset of TB in these patients on antiretroviral therapy were identified using logistic regression analysis. Results: After multivariate analysis, the independent factors associated with the onset of TB were: being married (OR = 4.456; 95% CI: 1.061-18.713), residence in the town of Tshopo (OR = 7.04; 95% CI: 1.168-42.47) as well as stages 3 and 4 of AIDS disease (OR = 29 95% CI: 4.563-184.872 and OR = 50.8 95% CI: 3.971-680.995). Conclusion: The results found by this study highlight the need for active TB testing in HIV-infected individuals. Particular emphasis should be placed on the category of patients on antiretroviral therapy who have one of the independent factors for the onset of TB.

Predictors tuberculosis HIV antiretroviral treatment Kisangani.

References (6)

  1. 1 Antiretrovirals and isoniazid preventive therapy in the prevention of HIV-associated tuberculosis in settings with limited health-care resources [DOI]
  2. 2 Tuberculosis incidence rate and risk factors among HIV-infected adults with access to antiretroviral therapy [DOI]
  3. 3 Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia: a multicentre case–control study [DOI]
  4. 4 Determinants of Tuberculosis Infection among Adult HIV Positives Attending Clinical Care in Western Ethiopia: A Case-Control Study [DOI]
  5. 5 Development of tuberculosis in human immunodeficiency virus infected patients receiving antiretroviral therapy [DOI]
  6. 6 Incident tuberculosis in HIV-positive children, adolescents and adults on antiretroviral therapy in South Africa [DOI]

Cited by 2

The incidence rate of tuberculosis and its associated factors among HIV-positive persons in Sub-Saharan Africa: a systematic review and meta-analysis

Temesgen Gebeyehu Wondmeneh, Ayal Tsegaye Mekonnen · BMC Infectious Diseases · 2023

Showing 1 of 2 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

63

Page views

0

PDF downloads

25

Outbound clicks

2

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.