Potential Hexokinase II Inhibition by Benzimidazole Anthelmintics: Albendazole, Mebendazole and Fenbendazole
Journal of Pharmaceutical Research International · pp. 80–86 · Published 5 Feb 2021
10.9734/jpri/2020/v32i4631105Abstract
The nitrogen heterocycle benzimidazoles have been known to be anthelmintic drugs. Beyond that role, the benzimidazoles exhibit other pharmacological potential as anti-inflammatory, antiulcer, anti-hypertensive and anticancer agents. A growing body of evidence supports the anticancer efficiency via treatment with benzimidazoles. The target proteins for pharmacological effect appear to be cell microtubules. However, it has been reported that the benzimidazoles could inhibit hexokinase II, which is a critical factor in the glycolysis pathway in humans. Here, we discuss on the most common benzimidazoles such as albendazole, mebendazole and fenbendazole and focus on the potential anticancer activities of the target enzyme hexokinase II. This review would give better insight in development of target-specific benzimidazole derivatives as potential anticancer therapeutics.
Cited by 2
Osaiyuwu, C. O., Ugbomoiko, D. O., Omosigho, P. O. · International Journal of Public Health and Pharmacology · 2025
Hillary J. Navarro, Jhawn G. Saul, Andrew E. Huckleby · Journal of Pharmaceutical Research International · 2022
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