Potential Application of Wharton's Jelly-derived Mesenchymal Stem Cells Conditioned Medium (WJMSCs-CM) on Delayed Wound Healing: A Case Report

Abstract

Delayed wound healing refers to wounds that do not repair the wounded tissue's integrity in a timely manner, prolonging the inflammatory, proliferative, and remodelling phases of healing. Delayed wound healing increases the chance of infection, causing discomfort, lowering the quality of life, and increasing healthcare costs. One of the newest techniques to heal wounds is to use the conditioned medium (secretome) of mesenchymal stem cells. One case was reported, a seventeen-year-old man appeared with a one-month history of wound in his left neck that had not healed after a keloid removal surgery. The wound was treated with a 10% Wharton's Jelly-derived Mesenchymal Stem Cells Conditioned Medium (WJMSCs-CM) topical gel. During the two weeks of the intervention, the results are encouraging. The lesion has reduced in size and turned into a closed wound.