Skip to content
Research Article Open access CC BY 4.0

Possible Ameliorative and Preventive Effect of Leaf Extract of Andrographis paniculata on Atherosclerosis: An Experience with Isoproterenol Induced Wistar Rats

E. I. Onwubuya, A. A. Oladejo, O. A. Kalu, I. K. Ndubueze

Journal of Complementary and Alternative Medical Research · pp. 1–8 · Published 5 Jul 2023

10.9734/jocamr/2023/v23i1467

Abstract

Atherosclerosis has been regarded as one of the leading causes of death in modern-day man worldwide. The use of medicinal plants especially Andrographis paniculata in the treatment of chronic diseases, particularly atherosclerotic disorder is becoming popular. This study aimed to evaluate the possible ameliorative and preventive effect of leaf extract of Andrographis paniculata on atherosclerosis in isoproterenol-induced Wistar rats. Thirty animals were randomly divided into five groups (A-E) of six animals per group, per cage. Groups A, B and C served as the treatment groups and were orally pre-treated with 100, 200 and 400 mg/kg body weight extract of A. paniculata for fourteen days, group D served as the positive control group and was administered 10 mg atorvastatin while group E served as the negative control and was administered distilled water. On the fifteenth and sixteenth day, 150 mg/kg isoproterenol was administered intraperitoneal at 24 h intervals to all the animals and were subsequently sacrificed. The sera obtained were used for a bioassay study. Analysis of serum total cholesterol, triglycerides, low density lipoprotein (LDL) and high density lipoprotein (HDL) were carried out using standard methods. The result obtained revealed a significant decrease (p>0.05) in the serum total cholesterol, triglycerides and LDL in the extract treated groups in a dose dependent manner when compared with the untreated control while there was a significant increase in the serum HDL level of extract treated group compared to the untreated control; thereby supporting the protective effect of A. paniculata against atherosclerotic disorder.

Atherosclerosis Andrographis paniculata chronic diseases isoproterenol

References (21)

  1. 1 Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis [DOI]
  2. 2 Herbal versus synthetic drugs; beliefs and facts.
  3. 3 Andrographis paniculata: a review of pharmacological activities and clinical effects.
  4. 4 The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis [DOI]
  5. 5 Andrographolide, a natural anti-inflammatory agent: An Update [DOI]
  6. 6 The Functional Role of Lipoproteins in Atherosclerosis: Novel Directions for Diagnosis and Targeting Therapy [DOI]
  7. 7 New Progress in Early Diagnosis of Atherosclerosis [DOI]
  8. 8 Review on Nutritional Importance and Anti-nutritional Factors of Legumes [DOI]
  9. 9 Evaluations of Andrographolide-Rich Fractions of Andrographis paniculata with Enhanced Potential Antioxidant, Anticancer, Antihypertensive, and Anti-Inflammatory Activities [DOI]
  10. 10 Nanomedicine and Nanobiotechnology [DOI]
  11. 11 Percentage oil yield and physiochemical properties of different groundnut species ( Arachis hypogaea ) [DOI]
  12. 12 Immunomodulatory effects of Andrographis paniculata extract in healthy adults – An open-label study [DOI]
  13. 13 Antidiabetic effects of Andrographis paniculata supplementation on biochemical parameters, inflammatory responses, and oxidative stress in canine diabetes [DOI]
  14. 14 Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: A 45 years bibliometrics analysis [DOI]
  15. 15 Antihyperlipidemic Effect of Ethanolic Extract of Hibiscus rosa sinensis Flowers in Hyperlipidemic Rats
  16. 16 Inhibitory Effects of Bryophyllum pinnatum Leaf Extract on Inflammatory Biomarkers [DOI]
  17. 17 Cardio-Protective Effect of the Leaf Extract of Andrographis paniculata in Isoproterenol-Induced Myocardial Infarction [DOI]
  18. 18 Cardiovascular Risk Factor Profile among Public Servants in a Developing Country: A Look at the Prevalence of Metabolic Syndrome in a Nigerian University Community
  19. 19 International Journal of Molecular Sciences [DOI]
  20. 20 International Journal of Nutrition and Food Sciences [DOI]
  21. 21 National Cholesterol Education Program (Ncep) [DOI]

Cited by 4

Protective Effect of Annona muricata Leaf Extract against Electrolytes Imbalance in Wistar Rats Induced with Acute Myocardial Infarction

Oladejo, A.A., Okeke, C.B., Okeke C.M., Iloanya, E. L., Adeyemi, M. A., Anyanwu, R. O., Apalowo, D., Onyenweaku, O. G. · Journal of Advances in Medical and Pharmaceutical Sciences · 2024

Investigating the Cardio-protective Activity of Agaricus bisporus in Wistar Rats Induced with Myocardial Infarction

Adebayo Afees Oladejo, Emmanuel Ikechukwu Onwubuya, Ofia Anya Kalu · Cardiology and Angiology An International Journal · 2024

Investigating the Cardio-protective Activity of Volvariella volvacea in Isoproterenol-induced Myocardial Infarction Using Animal Model: An In vivo Approach

Ofia Anya Kalu, Emmanuel Ikechukwu Onwubuya, Adebayo Afees Oladejo · Journal of Complementary and Alternative Medical Research · 2024

Showing 3 of 4 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

34

Page views

0

PDF downloads

5

Outbound clicks

4

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.