Polymorphism of pfk13-propeller in Niger: Detection of Novel Mutations
Ibrahim Maman Laminou, Mahaman Moustapha Lamine, Boubacar Mahamadou, Oumou Maïga Ascofaré, Alioune Dièye
Journal of Advances in Medicine and Medical Research · pp. 1–5 · Published 23 Jun 2017
10.9734/JAMMR/2017/34192Abstract
Aim: Artemisinin resistance was confirmed in Southeast Asia in 2009, and a molecular marker of resistance to artemisinin as point mutations in the region of the kelch13 gene (k13) coding for the C-terminal propeller domain of Kelch13 (K13-propeller) gene, was discovered in Cambodia in 2013. Methods: In this context, we examined the polymorphism of k13-propeller by sequencing 602 Plasmodium falciparum isolates collected from patients with uncomplicated malaria in Niamey, Niger, during the rainy season of 2013. Results: We observed thirteen single-nucleotide polymorphisms (SNPs) including eight specific to Niger at a low frequency from 0.02% to 2.7%. The key mutations associated with delayed parasite clearance time in Southeast Asia (SEA) and with decrease of the ring-stage sensitivity to artemisinin in vitro (C580Y, R539T, Y493H, I543T and N458Y) were not observed. However, five particular non-synonymous mutations were found in our study area: M472I, Y558C, K563R, P570L and P615S and were not reported elsewhere. Conclusion: These results suggest a genetic variability of P. falciparum k13-propeller domain in Niamey, Niger.
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