Skip to content
Research Article Open access CC BY 4.0

Plasma Lipid Profile and Apolipoproteins in Patients with Coronary Artery Diseases and Healthy Persons, in Sana'a City, Yemen

Khater Gh. H. AL-Hamoodi, Fairouz K. AL-Showafi, Saeed M. AL-Shaibani, Mohammad M. AL-Kebsi, Mubarak Ghaleb H. Al-hamodi, Tibyan Abd Almajed Altaher, Ghanem Mohammed Mahjaf, Waha Ismail Yahia Abdelmula, Babbiker Mohammed Taher Gorish

International Journal of Biochemistry Research & Review · pp. 21–30 · Published 22 Jan 2024

10.9734/ijbcrr/2024/v33i1849

Abstract

Background: Cardiovascular disease (CVD) is the primary cause of all disease loads and accounts for almost half of all fatalities. The early detection of coronary artery disease (CAD) has drawn a lot of attention because it is anticipated that the global burden of cardiovascular disease will rise by almost 75% by 2020. They are easily oxidized, which causes an increase in affinity for arterial proteoglycans and a decrease in affinity for LDL receptors. It demonstrates significant CAD importance. Objective: The measurement of plasma lipid profiles and apolipoproteins (ApoA-1, ApoB, and Apo B/A-1 ratio) in healthy individuals and patients suffering from coronary artery disease. Methods: In this cross-sectional comparative study, 90 Yemeni subjects aged 45 to 70 years were divided into three groups: Group I: 30 cases as CAD positive (CAD+). Group II: 30 cases CAD negative (CAD -). Group III: 30 healthy person was as control. A standardized questionnaire was administered to collect demographic and clinical data from participants. Venous blood (10 ml) was collected from each individual and divided into two portions. The first portion was 5 ml in plain tubes, ApoA-1 and Apo B vacuum tubes for freezing at -20°C until analysis. 5ml in a plain tube for measuring fasting blood glucose, and lipid profile. Results: ApoB and Apo B/A ratios were significantly higher in CAD+ and CAD− subjects compared to controls. In addition, ApoB and Apo B/A ratios were significantly higher in CAD+ subjects compared to CAD- subjects. (P. value =0.002). In contrast, Apo A-1 was significant in CAD+ compared to CAD- and controls, and not significantly different between CAD and controls P. value = (0.001, 0.032). Furthermore, FBS and LDL-c were significantly higher in CAD+ compared to CAD subjects (P value = 0.05). In contrast, HDL-c was significantly lower in CAD+ compared to CAD and controls, with no significant difference between CAD and controls (P value=0.038, 0.004, 0.70). However, TG was not substantially different between CAD- and controls, but it was significantly greater in CAD+ compared to controls (P. value =0.002, 0.09, 0.31). Nevertheless, there was no difference in TC between study groups (P. value = 0.08, 0.12, 0.98). Conclusions: The degree of CAD is significantly positively correlated with WHR. More important than overall obesity, abdominal obesity is a risk factor for coronary heart disease (CHD). A significant positive connection has been observed between the Apo B/Apo A ratio and CAD. One thing to think about as a CAD risk factor is Apo B.

Apolipoprotein LDL Cardiovascular disease Yemen

References (45)

  1. 1 Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 [DOI]
  2. 2 Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy [DOI]
  3. 3 Inflammation and Atherosclerosis [DOI]
  4. 4 Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 [DOI]
  5. 5 Progress and challenges in translating the biology of atherosclerosis [DOI]
  6. 6 The plasma lecithin:cholesterol acyltransferase reaction [DOI]
  7. 7 Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease [DOI]
  8. 8 HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study. [DOI]
  9. 9 Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease [DOI]
  10. 10 Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study [DOI]
  11. 11 Epidemiological studies of CHD and the evolution of preventive cardiology [DOI]
  12. 12 The Global Burden of Ischemic Heart Disease in 1990 and 2010 [DOI]
  13. 13 The apoB/apoA‐I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid‐lowering therapy – a review of the evidence [DOI]
  14. 14 Ischemic Heart Disease, Atherosclerosis, and Longevity [DOI]
  15. 15 Lipids, Apolipoproteins, and Their Ratios in Relation to Cardiovascular Events With Statin Treatment [DOI]
  16. 16 High-Density Lipoprotein Function, Dysfunction, and Reverse Cholesterol Transport [DOI]
  17. 17 Genetics of coronary artery disease and myocardial infarction [DOI]
  18. 18 Prevalence of coronary heart disease--United States, 2006-2010.
  19. 19 Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III [DOI]
  20. 20 Apolipoprotein Measurements: Is More Widespread Use Clinically Indicated? [DOI]
  21. 21 Serum Lipoproteins and Coronary Heart Disease in a Population Study of Hawaii Japanese Men [DOI]
  22. 22 Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders [DOI]
  23. 23 Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque. [DOI]
  24. 24 Familial Hypercholesterolemia: A Genetic Defect in the Low-Density Lipoprotein Receptor [DOI]
  25. 25 The Role of Triglyceride-Rich Lipoprotein Families in the Progression of Atherosclerotic Lesions as Determined by Sequential Coronary Angiography From a Controlled Clinical Trial [DOI]
  26. 26 Biomaterials for Clinical Applications [DOI]
  27. 27 Errors that result from using the TC/HDL C ratio rather than the apoB/apoA‐I ratio to identify the lipoprotein‐related risk of vascular disease [DOI]
  28. 28 Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease [DOI]
  29. 29 Apo B/Apo A-I Ratio is Statistically A Better Predictor of Cardiovascular Disease (CVD) than Conventional Lipid Profile: A Study from Kathmandu Valley, Nepal [DOI]
  30. 30 The Relationship between Body Mass Index and the Severity of Coronary Artery Disease in Patients Referred for Coronary Angiography [DOI]
  31. 31 A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke [DOI]
  32. 32 ISCHÆMIC HEART-DISEASE IN RELATION TO FASTING VALUES OF PLASMA TRIGLYCERIDES AND CHOLESTEROL [DOI]
  33. 33 Serum Triglycerides in Health and in Ischemic Heart Disease [DOI]
  34. 34 Overview of atherosclerosis [DOI]
  35. 35 Apo B/Apo A-I ratio in central and peripheral arterial diseases [DOI]
  36. 36 Serum lipids, hypertension and coronary artery disease [DOI]
  37. 37 A MECHANISM BY WHICH HIGH-DENSITY LIPOPROTEINS MAY SLOW THE ATHEROGENIC PROCESS [DOI]
  38. 38 The inheritance of familial hypercholesterolemia [DOI]
  39. 39 General and Systematic Pathology [DOI]
  40. 40 CVD risk assessment: do we need the metabolic syndrome or better global cardiometabolic risk calculators? [DOI]
  41. 41 Screening Low-Risk Individuals for Coronary Artery Disease [DOI]
  42. 42 Waist-related anthropometric measures: Simple and useful predictors of coronary heart disease in women [DOI]
  43. 43 Levels of apolipoproteins as risk factors for coronary artery disease [DOI]
  44. 44 Modeling, Programming and Simulations Using LabVIEW™ Software
  45. 45 National journal of physiology, pharmacy and pharmacology

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

46

Page views

0

PDF downloads

6

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.