Phytonutrient Screening and In vitro Antibacterial and Antifungal Properties of Polar and Nonpolar Extracts of Albizia gummifera, Prunus africana, and Combretum molle from Mount Elgon Region, Kenya
Simone Pierrette Nguimbous, John Muthini Maingi, Alphonse Wafula Wanyonyi, Shem Peter Mutua Mutuiri
Journal of Advances in Microbiology · pp. 1–13 · Published 2 Jan 2024
10.9734/jamb/2024/v24i1780Abstract
Background: Globally, and particularly in less-developed countries, one of the principal factors associated with morbidity and mortality is infectious diseases. Over the years, the abuse and misuse of pharmaceutical products have caused an increase in resistant microbes, and consequently, today, the rate of infectious disease cases continues to increase to dangerously high levels as most medications have lost their efficacy. This indicates that there’s a need for new effective medications and calls for active research in drug discovery to curb this dangerous trend. Results: Obtained data demonstrated the presence of different bioactive compounds in the tested plant extracts such as glycosides, alkaloids, tannins, terpenoids, saponins, and phenols. Using the Kirby-Bauer disc diffusion method, P. africana methanol and ethyl acetate extracts showed significantly bigger inhibition zones compared to the rest against S. aureus (excluding controls). None of the tested extracts, however, were able to inhibit C. albicans and E. coli. The P. africana methanolic extract and the A. gummifera hexane, ethyl acetate, and methanolic extracts all inhibited the growth of S. aureus at the same minimum concentration of 31.25 mg/ml. The methanolic extract of C. molle exhibited the least activity against S. aureus, with an MIC of 250 mg/ml and mean zones of inhibition of 9.33±0.33 mm. Conclusions: This study revealed the presence of various phytoconstituents in crude extracts of the selected medicinal plants, but also highlighted the resistance of E. coli and C. albicans to these phytochemicals. The P. africana methanolic extract showed strongest inhibitory effect against S. aureus compared to the other plant extracts. The highest susceptibility was demonstrated by S. aureus, while E. coli and C. albicans were resistant to all the extracts. These findings support the usage of A. gummifera, P. africana, and C. molle in folk medicine against infections caused by S. aureus and highlight them as potential sources of phytonutrients for the development of new drugs.
References (51)
- 1 Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis. [DOI]
- 2 THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY [DOI]
- 3 Trends in maternal mortality, 1990–2008 [DOI]
- 4 Agroforestree Database: a tree reference and selection guide. Version 4.
- 5 Kirby-Bauer Disk Diffusion Susceptibility Test Protocol
- 6 Tropical animal health and production [DOI]
- 7 Antibacterial action of several tannins against Staphylococcus aureus [DOI]
- 8 Plectranthus: A review of ethnobotanical uses [DOI]
- 9 International Journal of Biological and Chemical Sciences
- 10 Screening of Medicinal Plants for Secondary Metabolites
- 11 Biologically active pentacyclic triterpenes and their current medicine signification [DOI]
- 12 Controlling Antimicrobial Resistance in Hospitals: Infection Control and Use of Antibiotics [DOI]
- 13 Antileishmanial activity and immune modulatory effects of tannins and related compounds on Leishmania parasitised RAW 264.7 cells [DOI]
- 14 Antimicrobial activities evaluation and phytochemical screening of some selected medicinal plants: A possible alternative in the treatment of multidrug-resistant microbes [DOI]
- 15 A study of the medicinal plants used by the Marakwet Community in Kenya [DOI]
- 16 Extracts from the Shoots of Arctotis arctotoides Inhibit the Growth of Bacteria and Fungi [DOI]
- 17 Evaluation of antimicrobial activity of some plant extracts against antibiotic susceptible and resistant bacterial strains causing wound infection [DOI]
- 18 Ongoing challenges in the management of malaria [DOI]
- 19 Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus [DOI]
- 20 Tannin inhibits HIV-1 entry by targeting gp41.
- 21 Antibacterial and antibiotic resistance modifying activity of the extracts from allanblackia gabonensis, combretum molle and gladiolus quartinianus against Gram-negative bacteria including multi-drug resistant phenotypes [DOI]
- 22 Polarisation effects on the solvation properties of alcohols [DOI]
- 23 Naturally Occurring Coumarins and Related Physiological Activities [DOI]
- 24 Phytochemical screening of tanzanian medicinal plants. I [DOI]
- 25 In vitro antimicrobial activity of extracts and compounds of some selected medicinal plants from Cameroon [DOI]
- 26 Antibacterial and cytotoxic activity of Brazilian plant extracts - Clusiaceae [DOI]
- 27 Treatment of Diarrhoea in Rural African Communities: An Overview of Measures to Maximise the Medicinal Potentials of Indigenous Plants [DOI]
- 28 Bioactive constituents in Prunus africana: Geographical variation throughout Africa and associations with environmental and genetic parameters [DOI]
- 29 Prunus africana: a monograph
- 30 Antimycobacterial evaluation of fifteen medicinal plants in South Africa [DOI]
- 31 Antimicrobial resistance [DOI]
- 32 Ecological and Anthropological Threats to Ethno-Medicinal Plant Resources and their Utilization in Maasai Communal Ranches in the Amboseli Region of Kenya [DOI]
- 33 The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera [DOI]
- 34 A Text-Book of Pharmacognosy, 6th Edition [DOI]
- 35 The potential use of Prunus africana for the control, treatment and management of common fungal and bacterial infections [DOI]
- 36 Phytochemical and Anti-Inflammatory Analysis of Prunus africana Bark Extract [DOI]
- 37 In vitro antimicrobial activity of Combretum molle (Combretaceae) against Staphylococcus aureus and Streptococcus agalactiae isolated from crossbred dairy cows with clinical mastitis [DOI]
- 38 In vitro anti-Neisseria gonorrhoeae activity of Albizia gummifera and Croton macrostachyus
- 39 Phytochemical and Antimicrobial Studies Of Capparis thonningii And Capparis tomemtosa
- 40 Antimalarial activity of fractions isolated from Albizia gummifera and Aspilia mossambicensis crude extracts.
- 41 A review on phytochemicals and their activities
- 42 The in vitro antitrypanosomal activity of Albizia gummifera leaf extracts [DOI]
- 43 Phytochemical and acute toxicity studies of methanolic extracts of selected antimalarial plants of Nupeland, north central Nigeria [DOI]
- 44 Common plants used in the treatment of typhoid fever, their active components and toxicity related issues: A review [DOI]
- 45 Antimicrobial activity of crude and semi-purified fractions of Warburgia ugandensis against some pathogens [DOI]
- 46 EVALUATION OF PHARMACOGNOSTICAL CHARACTERS, PHYTOCHEMICAL SCREENING, AND IN-VITRO ANTIBACTERIAL ACTIVITY OF Clematis buchananianDE CANDOLLE (RANUNCULACEAE) [DOI]
- 47 Antibiotic resistance threats in the United States, 2019 [DOI]
- 48 Journal of Pharmacognosy and Phytochemistry [DOI]
- 49 Middle-East Journal of Scientific Research [DOI]
- 50 Handbook of African medicinal plants [DOI]
- 51 Controlling Antimicrobial Resistance in Hospitals: Infection Control and Use of Antibiotics [DOI]
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