Phytochemicals against COVID -19, Pharmacological Perspectives: A Systematic Review
Ahmed S. Ali, Ekram A. Saied, Sharifa M. Theeban, Mazen M. Humayran, Assmaa Ahmed Shaker, Mohammed S. Almuhayawi, Abdelbagi Alfadil
Journal of Pharmaceutical Research International · pp. 34–55 · Published 6 Dec 2021
10.9734/jpri/2021/v33i53B33678Abstract
Background: Many publications discussed the potential role of medicinal plants in the management of COVID-19. However, clinical studies of the efficacy and safety of specified phytochemical(s) are limited. Objectives: To explore the pharmacological profile of specified compounds against COVID-19 Method: Systematic literature search of academic databases to explore specified phytochemicals for the management of COVID-19 using appropriate search terms. Rayyan software was used to organize 786 citations of which. 236 articles were included in this review. Results: Initially 70 compounds were identified to have a potential role in the management of COVID-19. In this review, 18 compounds were selected for further search Conclusion: In vitro anti-SARS-CoV-2activity has been demonstrated for a variety of natural compounds. However, preclinical research for most phytochemicals is scarce, and only a few compounds have been evaluated in clinical trials against COVID-19. A comprehensive pharmacological profile of these phytochemicals is urgently needed.
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