Phytochemical Study, Evaluation of Antihelminthic Potential and In silico Screening for Breast Cancer Using Mimosa pudica Linn.
Aravinth Velmurugan, Keerthana Chandramohan, Ganeshan Thamizhselvan, Yogesh Shokkalingam, Venkatesan Natarajan, Pradeepraj Devarasu, Thamizh Sendhamaraikannan
Journal of Pharmaceutical Research International · pp. 135–143 · Published 11 May 2024
10.9734/jpri/2024/v36i67529Abstract
Breast Cancer is a major health concern in India, where it is highly lethal for women because of unchecked cell proliferation and metastasis, which are frequently caused by interactions between the Estrogen Receptor Alpha and other receptors. Even though they work well, synthetic Anthelmintics come with dangers to the health of both humans and animals. Therefore, creating effective and safe Anthelmintics from plant sources is our main goal. We extracted Mimosa pudica leaves with ethanol using a Soxhlet system, and after concentration, we examined the extract using GC-MS, FTIR, and UV techniques. Estrogen Receptor structure and flavonoid compound databases from PubChem and Protein Data Bank were used for in silico testing against Breast Cancer and anthelmintic action, respectively. Using molecular docking and drug similarity investigations, the effectiveness of natural compounds against Breast Cancer was evaluated.
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