Phytochemical Composition and Antimalarial Activity of Methanol Leaf Extract of Crateva adansonii in Plasmodium berghei Infected Mice
A. N. Tsado, L. Bashir, S. S. Mohammed, I. O. Famous, A. M. Yahaya, M. Shu’aibu, T. Caleb
Biotechnology Journal International · pp. 165–173 · Published 12 Mar 2015
10.9734/BBJ/2015/16038Abstract
The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanolic leaf extract of Crateva adansonii was investigated for its antimalarial activity against Plasmodium berghei (NK65) infected mice. A total of 15 mice were intraperitoneally infected with chloroquine sensitive P. berghei strain and divided into 5 equal groups, group 1 served as negative control (untreated), groups 2,3 and 4 were given 200, 400 and 600 mg/kg Crateva adansonii methanolic leaves extract respectively while group 5 served as positive control and was given 5 mg\kg chloroquine for five days. The phytochemical constituents of the plant extract were evaluated to elucidate the possibilities of their antimalarial effects. The extract produced a significant dose dependent decrease in the level of parasitaemia when compared to infected untreated group. Also, the extract at dose of 400 mg/kg and 600 mg/kg produced significant increase in body weight and PCV of the infected mice as compare to mice treated with 200 mg/kg of extract and infected untreated group. Phytochemical screening showed that the leaves extract contains alkaloids, anthraquinones, tannins, flavonoids, saponins cardiac glycosides and steroids. It is concluded that Crateva adansonii could serve as a possible source of antimalarial compounds.
References (16)
- 1 Medicinal plants and traditional medicine in Africa
- 2 Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds [DOI]
- 3 Antimalarial drug discovery: efficacy models for compound screening [DOI]
- 4 Malaria: progress, perils, and prospects for eradication [DOI]
- 5 Methods of Plant Analysis [DOI]
- 6 Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials [DOI]
- 7 Interactions of condensed tannins with selected proteins [DOI]
- 8 Mouse Models of Blood-Stage Malaria Infections: Immune Responses and Cytokines Involved in Protection and Pathology [DOI]
- 9 Anabolic Steroid Use in Body Builders: An Echocardiographic Study of Left Ventricle Morphology and Function [DOI]
- 10 Phytochemical and Nutrient Evaluation of Spondias Mombin Leaves [DOI]
- 11 Malarial anaemia in African children associated with high oxygen-radical production [DOI]
- 12 Antimalarial Principles from Artemisia indica [DOI]
- 13 In vivo antimalarial and cytotoxic properties of Annona senegalensis extract [DOI]
- 14 Bioactive crude plant seed extracts from the NCAUR oilseed repository [DOI]
- 15 AN IN-VIVO EVALUATION OF ANTIPLASMODIAL ACTIVITY OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF AZADIRACHTA INDICA IN PLASMODIUM BERGHEI INFECTED BALB/c MICE
- 16 Comparative in vitro assessment of the antiplasmodial activity of quinine - zinc complex and quinine sulphate [DOI]
Cited by 29
Baral Kedar, Ripu M. Kunwar, Rainer W. Bussmann · Ethnobotany of Mountain Regions · 2020
Showing 11 of 29 known citations — external sources report more than can currently be individually listed.
Related research
- Nutrient Analysis and Antimicrobial Activities of the Leaves and Fruit Pulp Extracts of Tetrapluera tetraptera on Clinical Bacteria Isolates — shares topic coverage
- Antibacterial and Phytochemical Activity of Gliricidia sepium against Poultry Pathogens — shares topic coverage
- Antibacterial Screening of Two Indigenous Nigerian Spices; Piper guineense and Xylopia aethiopica — shares topic coverage
- In vitro Antibacterial Activity of the Extracts of Peperomia pellucida (L) — shares topic coverage
- Phytochemical and Antibacterial Investigation of Leaf Extracts of Vernonia amygdalina — shares topic coverage
Article metrics
Real usage data collected on this platform.
30
Page views
0
PDF downloads
4
Outbound clicks
29
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.