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Research Article Open access CC BY 4.0

Pathogens Enter Mosquito’s Salivary Glands through the Existing Lesions in their Organs: A Potential Transmission Mechanism for Infectious Diseases

Jiman He

Asian Journal of Research in Infectious Diseases · pp. 28–36 · Published 10 Jun 2023

10.9734/ajrid/2023/v13i3269

Abstract

Whether pathogens in the ingested blood meal can enter the salivary glands of mosquitoes is a decisive factor in disease transmission. Unlike the known mosquito-borne pathogens (e.g. ZIKA, dengue, etc.), most human pathogens cannot enter the salivary glands of mosquitoes, and their survival time inside mosquito is usually short. Studies have reported that some mosquito species infected with certain mosquito-borne pathogens developed lesions in organs (e.g. holes in the midgut). Therefore, some of the pathogens which cannot enter the salivary glands of mosquitoes on their own (PWCESGMTO) may quickly enter using the existing lesions in the organs. This highly plausible issue has been neglected in research, and may involve the transmission of many infectious diseases. Since PWCESGMTOes can usually survive inside mosquitoes for only short period, successful transmission occurs only if mosquitoes bite a non-infected person before the ingested pathogens die. Therefore, the infected people should usually be in close proximity. The present paper discusses the neglected issue and the puzzling correlation between mosquitoes and three example diseases, and calls for urgent research into the issue.

Mosquito infectious disease transmission theory salivary glands

References (23)

  1. 1 Sexually transmitted disease surveillance [DOI]
  2. 2 Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting [DOI]
  3. 3 Estimated HIV incidence and prevalence in the United States 2010–2015
  4. 4 Population-Level HIV Declines and Behavioral Risk Avoidance in Uganda [DOI]
  5. 5 Tissue Barriers to Arbovirus Infection in Mosquitoes [DOI]
  6. 6 Human-to-Human Transmission of Monkeypox Virus, United Kingdom, October 2018 [DOI]
  7. 7 Mosquitoes and Mosquito Repellents: A Clinician's Guide [DOI]
  8. 8 An Update on the Global Epidemiology of Syphilis [DOI]
  9. 9 Non-canonical odor coding in the mosquito [DOI]
  10. 10 Mosquito antiviral defense mechanisms: a delicate balance between innate immunity and persistent viral infection [DOI]
  11. 11 Diagnoses of HIV infection in the United States and dependent areas, 2014
  12. 12 SALIVARY GLAND MORPHOLOGY AND VIRUS TRANSMISSION DURING LONG-TERM CYTOPATHOLOGIC WEST NILE VIRUS INFECTION IN CULEX MOSQUITOES [DOI]
  13. 13 Mother-to-child transmission and gestational syphilis: Spatial-temporal epidemiology and demographics in a Brazilian region [DOI]
  14. 14 Monkeypox in the United States: an occupational health look at the first cases.
  15. 15 Pathologic Changes in the Midgut of Culex tarsalis Following Infection with Western Equine Encephalomyelitis Virus [DOI]
  16. 16 Apoptosis in mosquito salivary glands: Sindbis virus-associated and tissue homeostasis [DOI]
  17. 17 Live In Vivo Imaging of Plasmodium Invasion of the Mosquito Midgut [DOI]
  18. 18 Mosquito Species Composition and Abundance in Quebec, Eastern Canada [DOI]
  19. 19 Brugia malayi microfilariae transport alphaviruses across the mosquito midgut [DOI]
  20. 20 Mechanism of Increased Dissemination of Chikungunya Virus in Aedes albopictus Mosquitoes Concurrently Ingesting Microfilariae of Dirofilaria immitis [DOI]
  21. 21 The invasion of the midgut of the mosquito Culex (Culex) quinquefasciatus Say, 1823 by the helminth Litomosoides chagasfilhoi [DOI]
  22. 22 Sexually Transmitted Diseases [DOI]
  23. 23 Sexually transmitted disease surveillance 2017 [DOI]

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