Pathogenesis of Periodontitis: An Overview
Wael Khalil, Georges Aoun, Marwa Jaffal, Maryse Nassif, Mazen Kurban
Journal of Advances in Medicine and Medical Research · pp. 113–122 · Published 12 Jul 2022
10.9734/jammr/2022/v34i2031476Abstract
Periodontitis is the severe inflammation of the tissues surrounding and supporting the tooth like gingiva, alveolar bone, and periodontal ligament. Many studies have tried to explain the pathogenesis of periodontitis focusing in many parameters such as the roles of the host pathways, the molecular and genetic factors, the bacterial biofilm mass, and the patient’s susceptibility. The main objective of this article is to review the most relevant and comprehensive models of the pathophysiology of periodontitis and emphasize factors including the presence of systemic conditions and genetic that play a crucial role in the pathogenesis of chronic and aggressive periodontitis.
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